Relationship of the American heart association's impact goals (Life's Simple 7) with risk of chronic kidney disease: Results from the atherosclerosis risk in communities (ARIC) cohort study

Background-as part of its 2020 impact goals,the american heart association developed the life's simple 7 metric for cardiovascular health promotion. the relationship between the life's simple 7 metric and incident chronic kidney disease (ckd) is unknown. methods and results-we estimated the association between life's simple 7 and incident ckd in 14 832 atherosclerosis risk in communities study participants. ideal levels of life's simple 7 health factors were the following: nonsmoker or quit >1 year ago; body mass index <25 kg/m2; ≥150 minutes/week of physical activity; healthy dietary pattern (high in fruits and vegetables,fish,and fiber-rich whole grains; low in sodium and sugar-sweetened beverages); total cholesterol <200 mg/dl; blood pressure <120/ 80 mm hg; and fasting blood glucose <100 mg/dl. at baseline,mean age was 54 years,55% were women,and 26% were african american. there were 2743 incident ckd cases over a median follow-up of 22 years. smoking,body mass index,physical activity,blood pressure,and blood glucose were associated with ckd risk (all p<0.01),but diet and blood cholesterol were not. ckd risk was inversely related to the number of ideal health factors (p-trend<0.001). a model containing the life's simple 7 health factors was more predictive of ckd risk than the base model including only age,sex,race,and estimated glomerular filtration rate (life's simple 7 health factors area under the roc curve: 0.73,95% ci: 0.72,0.74 versus base model area under the roc curve: 0.68,95% ci: 0.67,0.69; p<0.001). conclusions-the aha's life's simple 7 metric,developed to measure and promote cardiovascular health,predicts a lower risk of ckd. © 2016 the authors.