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Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation
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نویسنده
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lee j.j. ,britton k.a. ,pedley a. ,massaro j.m. ,speliotes e.k. ,murabito j.m. ,hoffmann u. ,ingram c. ,keaney j.f. ,vasan r.s. ,fox c.s.
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منبع
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journal of the american heart association - 2016 - دوره : 5 - شماره : 5
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چکیده
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Background: visceral adipose tissue (vat) and fatty liver differ in their associations with cardiovascular risk compared with subcutaneous adipose tissue (sat). several biomarkers have been linked to metabolic derangements and may contribute to the pathogenicity of fat depots. we examined the association between fat depots on multidetector computed tomography and metabolic regulatory biomarkers. methods and results: participants from the framingham heart study (n=1583,47% women) underwent assessment of sat,vat,and liver attenuation. we measured circulating biomarkers secreted by adipose tissue or liver (adiponectin,leptin,leptin receptor,fatty acid binding protein 4,fetuin-a,and retinol binding protein 4). using multivariable linear regression models,we examined relations of fat depots with biomarkers. higher levels of fat depots were positively associated with leptin and fatty acid binding protein 4 but negatively associated with adiponectin (all p<0.001). associations with leptin receptor,fetuin-a,and retinol binding protein 4 varied according to fat depot type or sex. when comparing the associations of sat and vat with biomarkers,vat was the stronger correlate of adiponectin (β=-0.28 [women]; β=-0.30 [men]; both p<0.001),whereas sat was the stronger correlate of leptin (β=0.62 [women]; β=0.49 [men]; both p<0.001; p<0.001 for comparing vat versus sat). although fetuin-a and retinol binding protein 4 are secreted by the liver in addition to adipose tissue,associations of liver attenuation with these biomarkers was not stronger than that of sat or vat. conclusions: sat,vat,and liver attenuation are associated with metabolic regulatory biomarkers with differences in the associations by fat depot type and sex. these findings support the possibility of biological differences between fat depots. © 2016 the authors. published on behalf of the american heart association,inc.,by wiley blackwell.
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کلیدواژه
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Adipokines; Adipose tissue; Biomarkers; Epidemiology; Obesity
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آدرس
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national heart,lung,and blood institute's and boston university's framingham heart study,framingham,ma, United States, national heart,lung,and blood institute's and boston university's framingham heart study,framingham,ma,united states,division of cardiovascular medicine,brigham and women's hospital,boston,ma,united states,harvard medical school,boston,ma, United States, national heart,lung,and blood institute's and boston university's framingham heart study,framingham,ma, United States, department of biostatistics,boston university,boston,ma, United States, division of gastroenterology,department of medicine,university of michigan,ann arbor,mi, United States, national heart,lung,and blood institute's and boston university's framingham heart study,framingham,ma,united states,section of general internal medicine,department of medicine,boston university school of medicine,boston,ma, United States, department of radiology,massachusetts general hospital,boston,ma, United States, division of cardiovascular medicine,university of massachusetts medical school,worcester,ma, United States, jr.,division of cardiovascular medicine,university of massachusetts medical school,worcester,ma, United States, national heart,lung,and blood institute's and boston university's framingham heart study,framingham,ma,united states,sections of cardiology and preventive medicine,evans department of medicine,whitaker cardiovascular institute,boston university school of medicine,boston,ma,united states,department of epidemiology,boston university school of public health,boston,ma, United States, national heart,lung,and blood institute's and boston university's framingham heart study,framingham,ma,united states,division of endocrinology,brigham and women's hospital,boston,ma, United States
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Authors
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