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Concentration of Smaller High-Density Lipoprotein Particle (HDL-P) Is Inversely Correlated With Carotid Intima Media Thickening After Confounder Adjustment: the Multi Ethnic Study of Atherosclerosis (MESA)
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نویسنده
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kim d.s. ,li y.k. ,bell g.a. ,burt a.a. ,vaisar t. ,hutchins p.m. ,furlong c.e. ,otvos j.d. ,polak j.f. ,arnan m.k. ,kaufman j.d. ,mcclelland r.l. ,longstreth w.t. ,jarvik g.p.
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منبع
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journal of the american heart association - 2016 - دوره : 5 - شماره : 5
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چکیده
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Background: recent studies have failed to establish a causal relationship between high-density lipoprotein cholesterol levels (hdl-c) and cardiovascular disease (cvd),shifting focus to other hdl measures. we previously reported that smaller/denser hdl levels are protective against cerebrovascular disease. this study sought to determine which of small+medium hdl particle concentration (hdl-p) or large hdl-p was more strongly associated with carotid intima-media thickening (cimt) in an ethnically diverse cohort. methods and results: in cross-sectional analyses of participants from the multi ethnic study of atherosclerosis (mesa),we evaluated the associations of nuclear magnetic resonance spectroscopy-measured small+medium versus large hdl-p with cimt measured in the common and internal carotid arteries,through linear regression. after adjustment for cvd confounders,low-density lipoprotein cholesterol (ldl-c),hdl-c,and small+medium hdl-p remained significantly and inversely associated with common (coefficient=-1.46 μm; p=0.00037; n=6512) and internal cimt (coefficient=-3.82 μm; p=0.0051; n=6418) after bonferroni correction for 4 independent tests (threshold for significance=0.0125; α=0.05/4). large hdl-p was significantly and inversely associated with both cimt outcomes before hdl-c adjustment; however,after adjustment for hdl-c,the association of large hdl-p with both common (coefficient=1.55 μm; p=0.30; n=6512) and internal cimt (coefficient=4.84 μm; p=0.33; n=6418) was attenuated. in a separate sample of 126 men,small/medium hdl-p was more strongly correlated with paraoxonase 1 activity (rp=0.32; p=0.00023) as compared to both total hdl-p (rp=0.27; p=0.0024) and large hdl-p (rp=0.02; p=0.41) measures. conclusions: small+medium hdl-p is significantly and inversely correlated with cimt measurements. correlation of small+medium hdl-p with cardioprotective paraoxonase 1 activity may reflect a functional aspect of hdl responsible for this finding. © 2016 the authors. published on behalf of the american heart association,inc.,by wiley blackwell.
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کلیدواژه
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Antioxidant; Carotid intima media thickening; Cerebrovascular disease; High-density lipoprotein cholesterol; High-density lipoprotein particle concentration; Paraoxonase 1
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آدرس
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division of medical genetics,department of medicine,university of washington school of medicine,seattle,wa,united states,department of genome sciences,university of washington school of medicine,seattle,wa,united states,department of biostatistics,university of washington school of public health,seattle,wa, United States, department of biostatistics,university of washington school of public health,seattle,wa, United States, department of epidemiology,university of washington school of public health,seattle,wa, United States, division of medical genetics,department of medicine,university of washington school of medicine,seattle,wa, United States, division of metabolism,endocrinology,and nutrition,department of medicine,university of washington school of medicine,seattle,wa, United States, division of metabolism,endocrinology,and nutrition,department of medicine,university of washington school of medicine,seattle,wa,united states,tsi incorporated,shoreview,mn, United States, division of medical genetics,department of medicine,university of washington school of medicine,seattle,wa,united states,department of genome sciences,university of washington school of medicine,seattle,wa, United States, labcorp,raleigh,nc, United States, department of radiology,tufts university school of medicine,boston,ma, United States, department of neurology,university of washington school of medicine,seattle,wa, United States, division of general medicine,department of medicine,university of washington school of medicine,seattle,wa,united states,department of epidemiology,university of washington school of public health,seattle,wa,united states,department of environmental and occupational health sciences,university of washington school of public health,seattle,wa, United States, department of biostatistics,university of washington school of public health,seattle,wa, United States, department of neurology,wake forest school of medicine,winston-salem,nc,united states,department of epidemiology,university of washington school of public health,seattle,wa, United States, division of medical genetics,department of medicine,university of washington school of medicine,seattle,wa,united states,department of genome sciences,university of washington school of medicine,seattle,wa, United States
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Authors
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