Reduced Kidney Function Is Associated With Cardiometabolic Risk Factors,Prevalent and Predicted Risk of Cardiovascular Disease in Chinese Adults: Results From the REACTION Study

Background: chronic kidney disease (ckd) increases cardiovascular disease (cvd) risk. however,the association of mildly reduced kidney function with cvd risk is unclear.methods and results: this study investigated the association of estimated glomerular filtration rate (egfr) with prevalent cvds,10-year framingham risk for coronary heart disease (chd),and 10-year risk of atherosclerotic cardiovascular diseases (ascvd) in 239 832 participants from the baseline of the risk evaluation of cancers in chinese diabetic individuals: a longitudinal study. with an interviewer-assisted questionnaire,we collected information on cvd,including reported chd,stroke,or myocardial infarction. chronic kidney disease-epidemiology collaboration (ckd-epi) equation was used to calculate egfr. compared with individuals with normal egfr (≥90 ml/min per 1.73 m(2)),those with decreased egfr (75-89,60-74,and <60 ml/min per 1.73 m(2)) had higher risk of prevalent obesity,diabetes mellitus,hypertension,and dyslipidemia in both men and women (p for trend all <0.001). moreover,a significantly higher 10-year framingham risk for chd and 10-year risk for ascvd was observed in both men and women with mildly decreased egfr (60-89 ml/min per 1.73 m(2)).conclusions: even mildly reduced egfr (under 90 ml/min per 1.73 m(2)) is associated with elevated 10-year framingham risk for chd and 10-year ascvd risk among chinese adults. © 2016 the authors. published on behalf of the american heart association,inc.,by wiley blackwell.