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Cerebral Microbleeds,Vascular Risk Factors,and Magnetic Resonance Imaging Markers: the Northern Manhattan Study
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نویسنده
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caunca m.r. ,del brutto v. ,gardener h. ,shah n. ,dequatre-ponchelle n. ,cheung y.k. ,elkind m.s.v. ,brown t.r. ,cordonnier c. ,sacco r.l. ,wright c.b.
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منبع
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journal of the american heart association - 2016 - دوره : 5 - شماره : 9
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چکیده
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Background: cerebral microbleeds (cmbs) represent intracerebral hemorrhages due to amyloid angiopathy or exposure to modifiable risk factors. few community-based stroke-free studies including blacks and hispanics have been done. methods and results: the northern manhattan study (nomas) is a stroke-free,racially and ethnically diverse cohort study. brain mri was performed in 1290 participants,925 of whom had available t2* gradient-recall echo data. we used multivariable logistic regression to examine the association of sociodemographics,vascular risk factors,apolipoprotein e (apoe) genotype,and brain mri markers with cmb presence and location. the prevalence of cmbs in our cohort was 5%. of the 46 participants with cmbs,37% had only deep cmbs,48% had only lobar cmbs,and 15% had cmbs in both locations. the difference in cmb distribution was not statistically significant across race/ethnic group or apoe genotype. in multivariable analyses,age (or [95% ci]: 1.09 [1.04,1.15]) and sbis (2.58 [1.01,6.59]) were positively associated with cmb presence,and diabetes medication use was negatively associated (0.25 [0.07,0.86]). conclusions: cmbs may represent the severity of vascular disease in this racially and ethnically diverse cohort. larger studies are needed to elucidate the association between diabetes medication use and cmb presence. © 2016 the authors. published on behalf of the american heart association,inc.,by wiley blackwell.
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کلیدواژه
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Cerebral microbleed; Magnetic resonance imaging; Risk factor
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آدرس
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evelyn f. mcknight brain institute and the neuroscience program,university of miami,miami,fl,united states,department of neurology,university of miami miller school of medicine,miami,fl, United States, department of neurology,the university of chicagoil, United States, evelyn f. mcknight brain institute and the neuroscience program,university of miami,miami,fl,united states,department of neurology,university of miami miller school of medicine,miami,fl, United States, department of neurology,university of california,san francisco,ca, United States, inserm,chu lille,u 1171,degenerative and vascular cognitive disorders,university of lille, France, department of biostatistics,mailman school of public health,columbia university,new york,ny, United States, department of epidemiology,mailman school of public health,columbia university,new york,ny,united states,department of neurology,college of physicians and surgeons,columbia university,new york,ny, United States, department of radiology and radiological science,medical university of south carolina,charleston,sc, United States, inserm,chu lille,u 1171,degenerative and vascular cognitive disorders,university of lille, France, evelyn f. mcknight brain institute and the neuroscience program,university of miami,miami,fl,united states,department of neurology,university of miami miller school of medicine,miami,fl,united states,department of public health sciences,university of miami miller school of medicine,miami,fl,united states,department of human genetics,university of miami miller school of medicine,miami,fl, United States, evelyn f. mcknight brain institute and the neuroscience program,university of miami,miami,fl,united states,department of neurology,university of miami miller school of medicine,miami,fl,united states,department of public health sciences,university of miami miller school of medicine,miami,fl, United States
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Authors
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