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   Impacts of renal sympathetic activation on atrial fibrillation: the potential role of the autonomic cross talk between kidney and heart  
   
نویسنده yu l. ,cardiovascular research institute wuhan university ,huang b. ,cardiovascular research institute wuhan university ,wang z. ,cardiovascular research institute wuhan university ,wang s. ,cardiovascular research institute wuhan university ,wang m. ,cardiovascular research institute wuhan university ,li x. ,cardiovascular research institute wuhan university ,zhou l. ,cardiovascular research institute wuhan university ,meng g. ,cardiovascular research institute wuhan university ,yuan s. ,cardiovascular research institute wuhan university ,zhou x. ,cardiovascular research institute wuhan university ,jiang h. ,cardiovascular research institute wuhan university
منبع journal of the american heart association - 2017 - دوره : 6 - شماره : 3
چکیده    Background-recent studies have demonstrated that there is a high variability of renal sympathetic nerve density distribution from proximal to distal renal artery segments. the aim of our study was to investigate the roles of renal sympathetic nerve stimulation (rss) on atrial fibrillation and cardiac autonomic nervous activity. methods and results-twenty-eight dogs were randomly assigned to the proximal rss group (p-rss,n = 7),middle rss group (m-rss,n = 7),distal rss group (d-rss,n = 7),and the control group (sham rss,n = 7). rss was performed using electrical stimulation on the bilateral renal arteries for 3 hours. effective refractory period and the window of vulnerability were measured at atrial and pulmonary veins sites. superior left ganglionated plexi (slgp) and left stellate ganglion (lsg) function and neural activity were determined. c-fos and nerve growth factor protein expression in the slgp and lsg were examined. only p-rss (1) caused pronounced blood pressure rises,induced a significant decrease in effective refractory period,and generated a marked increase in cumulative window of vulnerability and effective refractory period dispersion; (2) increased the frequency and amplitude of the neural activity in the slgp and lsg; (3) increased slgp and lsg function; and (4) upregulated the level of c-fos and nerve growth factor expression in the slgp and lsg. conclusions-this study demonstrated that renal sympathetic nerve activation induced by 3 hours of p-rss facilitated atrial fibrillation inducibility by upregulating cardiac autonomic nervous activity,suggesting a potential autonomic cross talk between kidney and heart. © 2017 the authors.
کلیدواژه Atrial fibrillation; Ganglionated plexus; Left stellate ganglion; Renal sympathetic nervous system
آدرس department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China, department of cardiology, Renmin Hospital of Wuhan University, hubei key laboratory of cardiology,wuhan,hubei, China
 
     
   
Authors l. ,wuhan university ,b. ,wuhan university ,z. ,wuhan university ,s. ,wuhan university ,m. ,wuhan university ,x. ,wuhan university ,l. ,wuhan university ,g. ,wuhan university ,s. ,wuhan university
  
 
 

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