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Midlife and late-life vascular risk factors and white matter microstructural integrity: the atherosclerosis risk in communities neurocognitive study
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نویسنده
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power m.c. ,tingle j.v. ,reid r.i. ,huang j. ,sharrett a.r. ,coresh j. ,griswold m. ,kantarci k. ,jack c.r. ,knopman d. ,gottesman r.f. ,mosley t.h.
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منبع
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journal of the american heart association - 2017 - دوره : 6 - شماره : 5
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چکیده
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Background- diffusion tensor imaging measures of white matter (wm) microstructural integrity appear to provide earlier indication of wm injury than wm hyperintensities; however,risk factors for poor wm microstructural integrity have not been established. our study quantifies the association between vascular risk factors in midlife and late life with measures of late-life wm microstructural integrity. methods and results- we used data from 1851 participants in aric (atherosclerosis risk in communities study) who completed 3-t magnetic resonance imaging,including diffusion tensor imaging,as part of the aric neurocognitive study (aric-ncs). we quantified the association among lipids,glucose,and blood pressure from the baseline aric visit (1987-1989,ages 44-65,midlife) and visit 5 of aric (2011-2013,ages 67-90,late life,concurrent with aric-ncs) with regional and overall wm mean diffusivity and fractional anisotropy obtained at aric visit 5 for aric participants. we also considered whether these associations were independent of or modified by wm hyperintensity volumes. we found that elevated blood pressure in midlife and late life and elevated glucose in midlife,but not late life,were associated with worse late-life wm microstructural integrity. these associations were independent of the degree of wm hyperintensity,and the association between glucose and wm microstructural integrity appeared stronger for those with the least wm hyperintensity. there was little support for an adverse association between lipids and wm microstructural integrity. conclusions- hypertension in both midlife and late life and elevated glucose in midlife are related to worse wm microstructural integrity in late life. © 2017 the authors.
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کلیدواژه
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Blood pressure; Epidemiology; Leukoencephalopathy; Risk factor; Type 2 diabetes mellitus
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آدرس
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department of epidemiology and biostatistics,george washington university milken institute school of public health,washington,dc, United States, center of biostatistics and bioinformatics,university of mississippi medical center,jackson,ms, United States, department of information technology,mayo clinic,rochester,mn, United States, department of neurology,university of mississippi medical center,jackson,ms, United States, department of epidemiology,johns hopkins university,baltimore,md, United States, department of epidemiology,johns hopkins university,baltimore,md, United States, center of biostatistics and bioinformatics,university of mississippi medical center,jackson,ms, United States, department of radiology,mayo clinic,rochester,mn, United States, department of radiology,mayo clinic,rochester,mn, United States, department of neurology,mayo clinic,rochester,mn, United States, department of epidemiology,johns hopkins university,baltimore,md,united states,department of neurology,johns hopkins university,baltimore,md, United States, department of medicine,university of mississippi medical center,jackson,ms, United States
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Authors
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