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Recurrent stroke in minor ischemic stroke or transient ischemic attack with metabolic syndrome and/or diabetes mellitus
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نویسنده
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chen w. ,pan y. ,jing j. ,zhao x. ,liu l. ,meng x. ,wang y. ,wang y. ,johnston s.c. ,wang z. ,xia h. ,li b. ,zhang g. ,ren x. ,ji c. ,zhang g. ,li j. ,lu b. ,wang l. ,feng s. ,wang d. ,tang w. ,li j. ,zhang h. ,li g. ,wang b. ,chen y. ,lian y. ,liu b. ,teng j. ,sui r. ,li l. ,yuan z. ,zang d. ,lu z. ,sun l. ,wang d. ,hou l. ,yuan d. ,cao y. ,li h. ,tan x. ,wang h. ,du h. ,liu m. ,wang s. ,liu q. ,zhang z. ,cui q. ,wang r. ,zhao j. ,zhang j. ,zhao j. ,bi q. ,qi x. ,liu j. ,li c. ,li l. ,pan x. ,zhang j. ,jiao d. ,han z. ,qian d. ,xiao j. ,xing y. ,du h. ,huang g. ,cui y. ,li y. ,feng l. ,gao l. ,xiao b. ,cao y. ,wu y. ,liu j. ,zhang z. ,dong z. ,wang l. ,he l. ,wang x. ,guo x. ,wang m. ,wang x. ,jiang j. ,zhao r. ,zhou s. ,hu h. ,he m. ,yu f. ,ouyang q. ,zhang j. ,xu a. ,qi x. ,wang l. ,shi f. ,guo f. ,wang j. ,zhao f. ,dou r. ,wei d. ,meng q. ,xia y. ,wang s. ,xue z. ,xu y. ,ma l. ,wang c. ,wu j. ,du y. ,wang y. ,xiao l. ,song f. ,hu w. ,chen z. ,liu q. ,zhang j. ,chen m. ,yuan x. ,liu z. ,li g. ,li x. ,tian t.
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منبع
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journal of the american heart association - 2017 - دوره : 6 - شماره : 6
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چکیده
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Background--we aimed to determine the risk conferred by metabolic syndrome (mets) and diabetes mellitus (dm) to recurrent stroke in patients with minor ischemic stroke or transient ischemic attack from the chance (clopidogrel in high-risk patients with acute non-disabling cerebrovascular events) trial. methods and results--in total,3044 patients were included. patients were stratified into 4 groups: neither,mets only,dm only,or both. mets was defined using the chinese diabetes society (cds) and international diabetes foundation (idf) definitions. the primary outcome was new stroke (including ischemic and hemorrhagic) at 90 days. a multivariable cox regression model was used to assess the relationship of mets and dm status to the risk of recurrent stroke adjusted for potential covariates. using the cds criteria of mets,53.2%,17.2%,19.8%,and 9.8% of patients were diagnosed as neither,mets only,dm only,and both,respectively. after 90 days of follow-up,there were 299 new strokes (293 ischemic,6 hemorrhagic). patients with dm only (16.1% versus 6.8%; adjusted hazard ratio 2.50,95% ci 1.89-3.39) and both (17.1% versus 6.8%; adjusted hazard ratio 2.76,95% ci 1.98-3.86) had significantly increased rates of recurrent stroke. no interaction effect of antiplatelet therapy by different mets or dm status for the risk of recurrent stroke (p=0.82 for interaction in the fully adjusted model of cds) was observed. using the mets (idf) criteria demonstrated similar results. conclusions--concurrent mets and dm was associated with an increased risk of recurrent stroke in patients with minor stroke and transient ischemic attack. © 2017 the authors.
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کلیدواژه
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Diabetes mellitus; Metabolic syndrome; Prognosis; Stroke
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آدرس
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department of neurology,beijing tiantan hospital,capital medical university,beijing,china,china national clinical research center for neurological diseases,beijing,china,center of stroke,beijing institute for brain disorders,beijing,china,beijing key laboratory of translational medicine for cerebrovascular disease,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing,china,department of epidemiology and health statistics,school of public health,capital medical university,beijing,china,china national clinical research center for neurological diseases,beijing,china,center of stroke,beijing institute for brain disorders,beijing,china,beijing key laboratory of translational medicine for cerebrovascular disease,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing,china,china national clinical research center for neurological diseases,beijing,china,center of stroke,beijing institute for brain disorders,beijing,china,beijing key laboratory of translational medicine for cerebrovascular disease,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing,china,china national clinical research center for neurological diseases,beijing,china,center of stroke,beijing institute for brain disorders,beijing,china,beijing key laboratory of translational medicine for cerebrovascular disease,beijing,china,beijing tiantan hospital, China, department of neurology,beijing tiantan hospital,capital medical university,beijing,china,china national clinical research center for neurological diseases,beijing,china,center of stroke,beijing institute for brain disorders,beijing,china,beijing key laboratory of translational medicine for cerebrovascular disease,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing,china,china national clinical research center for neurological diseases,beijing,china,center of stroke,beijing institute for brain disorders,beijing,china,beijing key laboratory of translational medicine for cerebrovascular disease,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing,china,china national clinical research center for neurological diseases,beijing,china,center of stroke,beijing institute for brain disorders,beijing,china,beijing key laboratory of translational medicine for cerebrovascular disease,beijing,china,beijing tiantan hospital, China, department of neurology,beijing tiantan hospital,capital medical university,beijing,china,china national clinical research center for neurological diseases,beijing,china,center of stroke,beijing institute for brain disorders,beijing,china,beijing key laboratory of translational medicine for cerebrovascular disease,beijing,china,beijing tiantan hospital, China, departments of neurology and epidemiology,university of california,san francisco, United States, taizhou first people's hospital, China, taiyuan iron and steel (group) co,ltd,general hospital, China, dagang oilfield gengeal hospital, China, penglai people's hospital, China, the third people's hospital of datong, China, the fourth central hospital of tianjin, China, the second hospital of hebei medical university, China, the first hospital of fangshan district,beijing, China, beijing puren hospital, China, tianjin ninghe district hospital, China, the people's hospital of zhengzhou, China, affiliated hospital of north china coal medical college, China, zhejiang zhoushan hospital, China, han dan central hospital, China, zhecheng people's hospital, China, shanxi medical university second hospital, China, baotou central hospital, China, the general hospital of changjiang river shipping, China, dalian economic and technological development zone hospital, China, first neurology department,affiliated hospital of north china coal medical college, China, the first affiliated hospital of zhengzhou university, China, first affiliated hospital of liaoning medical, China, lianyungang municipal hospital of tcm, China, central hospital in qiu county, China, tianjin first center hospital, China, renmin hospital of wuhan university, China, qingdao central hospital, China, baogang hospital, China, changzhi city people's hospital of shanxi province, China, halixun international peace hospital, China, people's hospital of linzi district,zibo, China, yantai city yantai mountain hospital, China, beijing pinggu district hospital, China, taiyuan central hospital, China, chengde central hospital, China, shijiazhuang central hospital, China, first neurology department,dalian municipal central hospital, China, xian 141 hospital, China, chengdu third municipal people's hospital, China, affiliated hospital of chifeng university, China, zhengzhou central hospital, China, zhejiang province lihuili hospital medical center,ningbo city, China, henan provincial people's hospital, China, jinzhong city second hospital, China, beijing anzhen hospital,capital medical university, China, beijing huairou district chinese medicine hospital, China, hebei medical university third hospital, China, first affiliated hospital shanxi medical unversity, China, hebei provincial people's hospital, China, guangzhou first municipal peoples hospital, China, central hospital in cangzhou, China, the chinese people's armed police force medical school affiliated hospital, China, zhejiang wenzhou medical college first affiliated hospital, China, jilin central hospital, China, anhui maanshan central hospital, China, beijing aviation industry central hospital, China, luhe hospital,tongzhou district,beijing, China, beijing fuxing hospital,capital medical university, China, the 306th hospital of p.l.a, China, the first affiliated hospital of tianjin university of chinese medicine, China, baiqiuen international peace hospital of people's liberation army, China, fourth affiliated hospital of china medical university, China, xiangya hospital central-south university, China, tangshan worker's hospital, China, the 1st hospital in handan, China, yangquan coal,(group) co,ltd,general hospital, China, tianjin tianhe hospital, China, nantong first people's hospital, China, the 1st hospital of zhangjiakou city, China, west china hospital,sichuan university, China, the second affiliated hospital of shandong university of tcm, China, fenyang hospital of shanxi province, China, zhejiang zhoushan putuo district people's hospital, China, xiyuan hospital of china academy of chinese traditional medicine, China, no. 2 people's hospital east in lianyungang city, China, affiliated hospital of qingdao university medical college, China, qilu hospital of shandong university, China, zibo hospital of traditional chinese medicine, China, beijing shijitan hospital, China, beijing haidian hospital, China, beijing shunyi district hospital, China, dalian third municipal hospital, China, the first affliated hospital of jinan university, China, navy genaral hospital of p.l.a, China, beijing second artillery general hospital, China, beijing daxing district hospital, China, sichuan province people's hospital, China, dalian municipal central hospital, China, the second hospital in baoding, China, the hospital combine traditional chinese and western medicine in cang zhou, China, the 309th hospital of p.l.a, China, liangxiang hospital of fangshan district,beijing, China, huaxin hospital first hospital of tsinghua university, China, tianjinhuanhu hospital, China, shijiazhuang first hospital, China, the first affiliated hospital of zhengzhou university, China, xinzhou city people's hospital, China, sichuan province people's hospital of deyang city, China, first hospital,jilin university, China, shandong provincial hospital, China, fujian province hospital, China, liaoyang city third people's hospital, China, handan city center hospital, China, beijing chaoyang hospital,capital medical university, China, beijing university of chinese medicine east hospital, China, hebei medical university fourth hospital, China, the fourth affiliated hospital of soochow university, China, zhejiang university of chinese medicine affiliated first hospital, China, affiliated hospital of kailuan company ltd, China, affiliated hospital of weifang medical university, China, the first hospital of harbin medical university, China, dalian friendship hospital, China, tianjin dagang hospital, China
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Authors
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