|
|
|
|
Platelet-derived factor V is a critical mediator of arterial thrombosis
|
|
|
|
|
|
|
|
نویسنده
|
ren m. ,li r. ,chen n. ,pang n. ,li y. ,deng x. ,wang l. ,luo m. ,liu y. ,hao h. ,liu y. ,sun h. ,wu j.
|
|
منبع
|
journal of the american heart association - 2017 - دوره : 6 - شماره : 7
|
|
چکیده
|
Background-coagulation factor v (fv) plays a key role in hemostasis,is present in plasma and platelets,and has both pro- and anticoagulant properties; however,the contribution of platelet-derived fv to arterial thrombosis remains undetermined. methods and results-using transgenic mice with various levels of fv gene expression that was restricted to the plasma or platelets,the roles of platelet fv were evaluated in the regulation of arterial thrombosis and platelet activation. mice with higher levels of platelet fv exhibited faster thrombotic occlusion of the carotid artery after injury compared with mice with lower platelet fv levels. infusion of platelets with higher levels of fv into transgenic mice with undetectable levels of platelet fv reduced the time to carotid artery occlusion. in contrast,infusion of purified recombinant plasma fv into mice with undetectable platelet fv levels failed to reduce the carotid occlusion times following injury. evaluation of isolated platelets revealed that platelet-derived fv was critical for the regulation of platelet activation. these effects were associated with an increased level of expression of p-selectin and increased cgmp in platelets. conclusions-we established that platelet-derived fv is a critical mediator of arterial thrombosis that involves platelet activation. © 2017 the authors.
|
|
کلیدواژه
|
Arterial; Coagulation; Factor V; Platelet; Thrombosis
|
|
آدرس
|
drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, drug discovery research center,southwest medical university,luzhou,sichuan, China, department of medicine,university of missouri,school of medicine,columbia,mo, United States, drug discovery research center,southwest medical university,luzhou,sichuan,china,laboratory for cardiovascular pharmacology of department of pharmacology,the school of pharmacy,southwest medical university,luzhou,sichuan,china,key laboratory of the ministry of education for medical electrophysiology,institute of cardiovascular research,southwest medical university,luzhou,sichuan,china,dalton cardiovascular research center,university of missouri,columbia,mo, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|