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Childhood age and associations between childhood metabolic syndrome and adult risk for metabolic syndrome,type 2 diabetes mellitus and carotid intima media thickness: the international childhood cardiovascular cohort consortium
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نویسنده
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koskinen j. ,magnussen c.g. ,sinaiko a. ,woo j. ,urbina e. ,jacobs d.r. ,steinberger j. ,prineas r. ,sabin m.a. ,burns t. ,berenson g. ,bazzano l. ,venn a. ,viikari j.s.a. ,hutri-kähönen n. ,raitakari o. ,dwyer t. ,juonala m.
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منبع
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journal of the american heart association - 2017 - دوره : 6 - شماره : 8
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چکیده
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Background--there is paucity of knowledge concerning the specific age in youth when the associations of metabolic syndrome (mets) begin to be operative. thus,we investigated the relation of age to the associations of childhood mets with adult mets,type 2 diabetes mellitus and high carotid intima-media thickness. methods and results--five thousand eight-hundred three participants were analyzed in 4 cohort studies (cardiovascular risk in young finns,bogalusa heart study,princeton lipid research study,insulin study). international cutoffs and previously used 75th percentile cutoffs were used for children to define mets and its components. mean follow-up period was 22.3 years. logistic regression was used to calculate risk ratios and 95% confidence intervals. childhood mets and overweight were associated with over 2.4-fold risk for adult mets from the age of 5 years onward. risk for type 2 diabetes mellitus was increased from the age of 8 (risk ratio,2.6-4.1; 95% confidence interval,1.35-6.76 and 1.12-7.24,respectively) onward for the 2 childhood mets criteria based on international cut-offvalues and for childhood overweight. risk for high carotid intima-media thickness was significant at ages 11 to 18 years in relation to childhood mets or overweight (risk ratio,2.44-4.22; 95% confidence interval,1.55-3.55 and 2.55-5.66,respectively). continuous childhood mets score was associated with adult mets from the age of 5,with type 2 diabetes mellitus from the age of 14 and with high carotid intima-media thickness from the age of 11 years onward. conclusions--adult mets was predicted by mets in childhood beginning at age 5. however,adult type 2 diabetes mellitus and subclinical atherosclerosis were not predicted by childhood data until after age 8. body mass index measurement alone at the same age points provided similar findings. © 2017 the authors and medtronic.
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کلیدواژه
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Carotid intima-media thickness; Metabolic syndrome; Obesity; Type 2 diabetes mellitus
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آدرس
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research centre of applied and preventive cardiovascular medicine,university of turku,finland,heart center,turku university hospital,turku, Finland, research centre of applied and preventive cardiovascular medicine,university of turku,finland,menzies institute for medical research,university of tasmania,hobart, Australia, department of pediatrics,university of minnesota,minneapolis,mn, United States, division of biostatistics and epidemiology,department of pediatrics,cincinnati children's hospital medical center,university of cincinnati college of medicine,cincinnati,oh, United States, division of cardiology,department of pediatrics,cincinnati children's hospital medical center and university of cincinnati,cincinnati,oh, United States, jr.,division of epidemiology and community health,school of public health,university of minnesota,minneapolis,mn, United States, department of pediatrics,university of minnesota masonic children's hospital,minneapolis,mn, United States, division of public health sciences,wake forest university school of medicine,winston-salem,nc, United States, murdoch children's research institute,royal children's hospital,parkville,australia,department of pediatrics,university of melbourne,parkville, Australia, department of epidemiology,college of public health,university of iowa,iowa city,ia, United States, department of epidemiology,tulane center for cardiovascular health,tulane university school of public health and tropical medicine,new orleans,la, United States, departments of epidemiology and biostatistics and bioinformatics,tulane university health sciences center,tulane university,new orleans,la, United States, menzies institute for medical research,university of tasmania,hobart, Australia, department of medicine,university of turku,finland,division of medicine,turku university hospital,turku, Finland, department of pediatrics,university of tampere school of medicine and tampere university hospital,tampere, Finland, department of clinical physiology and nuclear medicine,university of turku and turku university hospital,turku, Finland, murdoch children's research institute,royal children's hospital,parkville,australia,department of pediatrics,university of melbourne,parkville, Australia, department of medicine,university of turku,finland,division of medicine,turku university hospital,turku, Finland
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Authors
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