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Socioeconomic position is associated with carotid intima-media thickness in mid-childhood: the longitudinal study of Australian children
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نویسنده
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liu r.s. ,mensah f.k. ,carlin j. ,edwards b. ,ranganathan s. ,cheung m. ,dwyer t. ,saffery r. ,magnussen c.g. ,juonala m. ,wake m. ,burgner d.p. ,olds t. ,baur l. ,gold l. ,lycett k. ,kerr j.a. ,davies s.
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منبع
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journal of the american heart association - 2017 - دوره : 6 - شماره : 8
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چکیده
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Background--lower socioeconomic position (sep) predicts higher cardiovascular risk in adults. few studies differentiate between neighborhood and family sep or have repeated measures through childhood,which would inform understanding of potential mechanisms and the timing of interventions. we investigated whether neighborhood and family sep,measured biennially from ages 0 to 1 year onward,was associated with carotid intima-media thickness (imt) at ages 11 to 12 years. methods and results--data were obtained from 1477 families participating in the child health checkpoint study,nested within the longitudinal study of australian children. disadvantaged family and neighborhood sep was cross-sectionally associated with thicker maximum carotid imt in separate univariable linear regression models. associations with family sep were not attenuated in multivariable analyses,and associations with neighborhood sep were attenuated only in models adjusted for family sep. the difference in maximum carotid imt between the highest and lowest family sep quartile measured at ages 10 to 11 years was 10.7 μm (95% ci,3.4-18.0; p=0.004),adjusted for age,sex,pubertal status,passive smoking exposure,body mass index,blood pressure,and arterial lumen diameter. in longitudinal analyses,family sep measured as early as age 2 to 3 years was associated with maximum carotid imt at ages 11 to 12 years (difference between highest and lowest quartile: 8.5 μm; 95% ci,1.3-15.8; p=0.02). no associations were observed between sep and mean carotid imt. conclusions--we report a robust association between lower sep in early childhood and carotid imt in mid-childhood. further investigation of mechanisms may inform pediatric cardiovascular risk assessment and prevention strategies. © 2017 the authors and medtronic.
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کلیدواژه
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Atherosclerosis; CheckPoint; Prevention; Socioeconomic position; Subclinical atherosclerosis risk factor
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آدرس
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department of paediatrics,faculty of medicine,dentistry and health services,university of melbourne,parkville,australia,murdoch children's research institute,parkville, Australia, department of paediatrics,faculty of medicine,dentistry and health services,university of melbourne,parkville,australia,murdoch children's research institute,parkville,australia,royal children's hospital,parkville, Australia, melbourne school of population and global health,faculty of medicine,dentistry and health services,university of melbourne,parkville,australia,murdoch children's research institute,parkville, Australia, anu centre for social research and methods,research school of social sciences,college of arts and social sciences,the australian national university,canberra, Australia, murdoch children's research institute,parkville,australia,royal children's hospital,parkville, Australia, murdoch children's research institute,parkville,australia,royal children's hospital,parkville, Australia, murdoch children's research institute,parkville,australia,the george institute for global health,university of oxford, United Kingdom, murdoch children's research institute,parkville, Australia, research centre of applied and preventive cardiovascular medicine,university of turku,finland,menzies institute for medical research,university of tasmania,hobart,tas, Australia, murdoch children's research institute,parkville,australia,department of medicine,university of turku,finland,division of medicine,turku university hospital,turku, Finland, department of paediatrics,faculty of medicine,dentistry and health services,university of melbourne,parkville,australia,murdoch children's research institute,parkville,australia,department of paediatrics and the liggins institute,the university of auckland, New Zealand, department of paediatrics,faculty of medicine,dentistry and health services,university of melbourne,parkville,australia,murdoch children's research institute,parkville,australia,department of paediatrics,monash university,clayton, Australia, the george institute for global health,university of oxford, United Kingdom, the george institute for global health,university of oxford, United Kingdom, the george institute for global health,university of oxford, United Kingdom, the george institute for global health,university of oxford, United Kingdom, the george institute for global health,university of oxford, United Kingdom, the george institute for global health,university of oxford, United Kingdom
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Authors
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