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Prevalence and characteristics of carotid artery high-risk atherosclerotic plaques in Chinese patients with cerebrovascular symptoms: A Chinese atherosclerosis risk evaluation iI study
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نویسنده
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zhao x. ,hippe d.s. ,li r. ,canton g.m. ,sui b. ,song y. ,li f. ,xue y. ,sun j. ,yamada k. ,hatsukami t.s. ,xu d. ,wang m. ,yuan c. ,wang x. ,huang j. ,zhou c. ,chen m. ,gao x. ,song j. ,ji s. ,ji y. ,wang d. ,zhuang z. ,liu j. ,peng x. ,shi h. ,wang g. ,zhang b. ,zhu b. ,zhao h. ,xu j. ,jiang p. ,yang z. ,lin r. ,xie m. ,yang q. ,liang b. ,zhang j. ,wen z. ,cao y. ,bao h.
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منبع
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journal of the american heart association - 2017 - دوره : 6 - شماره : 8
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چکیده
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Background--carotid atherosclerotic plaque rupture is an important source of ischemic stroke. however,the prevalence of highrisk plaque (hrp) defined as plaques with luminal surface disruption,a lipid-rich necrotic core occupying > 40% of the wall,or intraplaque hemorrhage in chinese population remains unclear. this study uses carotid magnetic resonance imaging (cmri) to investigate hrp prevalence in carotid arteries of chinese patients with cerebrovascular symptoms. methods and results--patients with cerebral ischemic symptoms in the anterior circulation within 2 weeks and carotid plaque determined by ultrasound were recruited and underwent cmri. the hrp features were identified and compared between symptomatic and asymptomatic arteries. receiver-operating-characteristic analysis was used to calculate area-under-the-curve (auc) of stenosis and maximum wall thickness for discriminating presence of hrp. in 1047 recruited subjects,hrp detected by cmri was nearly 1.5 times more prevalent than severe stenosis (≥50%) in this cohort (28% versus 19%,p < 0.0001). approximately two thirds of hrps were found in arteries with < 50% stenosis. the prevalence of hrp in symptomatic carotid arteries was significantly higher than that of the contralateral asymptomatic carotid arteries (23.0% versus 16.4%,p=0.001). maximum wall thickness was found to be a stronger discriminator than stenosis for hrp (auc: 0.93 versus 0.81,p < 0.0001). conclusions--there are significantly more high-risk carotid plaques than carotid arteries with ≥50% stenosis in symptomatic chinese patients. a substantial number of hrps were found in arteries with lower grade stenosis and maximum wall thickness was a stronger indicator for hrp than luminal stenosis. © 2017 the authors and medtronic.
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کلیدواژه
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Atherosclerosis; Carotid artery; High-risk plaque; MRI; Prevalence
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آدرس
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center for biomedical imaging research,department of biomedical engineering,tsinghua university,beijing, China, department of radiology,university of washington,seattle,wa, United States, center for biomedical imaging research,department of biomedical engineering,tsinghua university,beijing, China, department of radiology,university of washington,seattle,wa, United States, department of radiology,beijing tiantan hospital,beijing, China, department of radiology,beijing hospital,beijing, China, department of radiology,peking university first hospital,beijing, China, department of radiology,fujian union hospital,fuzhou,china,department of radiology,fujian medical university union hospital,fuzhou, China, department of radiology,university of washington,seattle,wa, United States, department of radiology,university of washington,seattle,wa, United States, division of vascular surgery,university of washington,seattle,wa, United States, department of radiology,university of washington,seattle,wa, United States, department of radiology,the affiliated drum tower hospital of nanjing university medical school,nanjing, China, center for biomedical imaging research,department of biomedical engineering,tsinghua university,beijing,china,department of radiology,university of washington,seattle,wa, United States, department of radiology,peking university first hospital,beijing, China, department of radiology,beijing hospital,beijing, China, department of radiology,beijing hospital,beijing, China, department of radiology,beijing hospital,beijing, China, department of radiology,tianjin fourth central hospital,tianjin, China, department of radiology,tianjin fourth central hospital,tianjin, China, department of radiology,tianjin fourth central hospital,tianjin, China, department of radiology,the fourth affiliated hospital of harbin medical university,harbin, China, department of radiology,the fourth affiliated hospital of harbin medical university,harbin, China, department of radiology,the first hospital of qiqihar city,qiqihar, China, department of radiology,the first hospital of qiqihar city,qiqihar, China, department of radiology,the first hospital of qiqihar city,qiqihar, China, shandong medical imaging research institute,jinan, China, shandong medical imaging research institute,jinan, China, department of radiology,the affiliated drum tower hospital of nanjing university medical school,nanjing, China, department of radiology,the affiliated drum tower hospital of nanjing university medical school,nanjing, China, department of radiology,shanghai jiao tong university renji hospital,shanghai, China, department of radiology,shanghai jiao tong university renji hospital,shanghai, China, department of radiology,fujian medical university union hospital,fuzhou, China, department of radiology,fujian medical university union hospital,fuzhou, China, department of radiology,fujian medical university union hospital,fuzhou, China, department of radiology,sun yat-sen memorial hospital,sun yat-sen university,guangzhou, China, department of radiology,sun yat-sen memorial hospital,sun yat-sen university,guangzhou, China, department of radiology,sun yat-sen memorial hospital,sun yat-sen university,guangzhou, China, department of radiology,zhujiang medical university,guangzhou, China, department of radiology,zhujiang medical university,guangzhou, China, department of radiology,qinghai university affiliated hospital,xining, China, department of radiology,qinghai university affiliated hospital,xining, China
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Authors
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