|
|
|
|
Cyclooxygenases 1 and 2 differentially regulate blood pressure and cerebrovascular responses to acute and chronic intermittent hypoxia: Implications for sleep Apnea
|
|
|
|
|
|
|
|
نویسنده
|
beaudin a.e. ,pun m. ,yang c. ,nicholl d.d.m. ,steinback c.d. ,slater d.m. ,wynne-edwards k.e. ,hanly p.j. ,ahmed s.b. ,poulin m.j.
|
|
منبع
|
journal of the american heart association - 2014 - دوره : 3 - شماره : 3
|
|
چکیده
|
Background: obstructive sleep apnea (osa) is associated with increased risk of cardiovascular and cerebrovascular disease resulting from intermittent hypoxia (ih)-induced inflammation. cyclooxygenase (cox)-formed prostanoids mediate the inflammatory response,and regulate blood pressure and cerebral blood flow (cbf),but their role in blood pressure and cbf responses to ih is unknown. therefore,this study's objective was to determine the role of prostanoids in cardiovascular and cerebrovascular responses to ih. methods and results: twelve healthy,male participants underwent three,6-hour ih exposures. for 4 days before each ih exposure,participants ingested a placebo,indomethacin (nonselective cox inhibitor),or celebrex® (selective cox-2 inhibitor) in a double-blind,randomized,crossover study design. pre- and post-ih blood pressure,cbf,and urinary prostanoids were assessed. additionally,blood pressure and urinary prostanoids were assessed in newly diagnosed,untreated osa patients (n=33). nonselective cox inhibition increased pre-ih blood pressure (p≤0.04) and decreased pre-ih cbf (p=0.04) while neither physiological variable was affected by cox-2 inhibition (p≥0.90). post-ih,map was elevated (p≤0.05) and cbf was unchanged with placebo and nonselective cox inhibition. selective cox-2 inhibition abrogated the ih-induced map increase (p=0.19),but resulted in lower post-ih cbf (p=0.01). prostanoids were unaffected by ih,except prostaglandin e2 was elevated with the placebo (p=0.02). finally,osa patients had elevated blood pressure (p≤0.4) and cox-1 formed thromboxane a2 concentrations (p=0.02). conclusions: cox-2 and cox-1 have divergent roles in modulating vascular responses to acute and chronic ih. moreover,cox-1 inhibition may mitigate cardiovascular and cerebrovascular morbidity in osa. clinical trial registration: url: www.clinicaltrials.gov. unique identifier: nct01280006. © 2014 the authors.
|
|
کلیدواژه
|
Blood pressure; Cerebrovascular circulation; Intermittent hypoxia; Obstructive sleep apnea; Prostaglandins
|
|
آدرس
|
department of physiology and pharmacology,university of calgary,calgary,ab,canada,faculty of medicine,university of calgary,calgary,ab, Canada, department of physiology and pharmacology,university of calgary,calgary,ab,canada,faculty of medicine,university of calgary,calgary,ab, Canada, faculty of science,university of calgary,calgary,ab, Canada, libin cardiovascular institute of alberta,university of calgary,calgary,ab,canada,faculty of medicine,university of calgary,calgary,ab, Canada, department of physiology and pharmacology,university of calgary,calgary,ab,canada,faculty of medicine,university of calgary,calgary,ab, Canada, department of physiology and pharmacology,university of calgary,calgary,ab, Canada, hotchkiss brain institute,university of calgary,calgary,ab,canada,faculty of veterinary medicine,university of calgary,calgary,ab, Canada, department of medicine,university of calgary,calgary,ab,canada,hotchkiss brain institute,university of calgary,calgary,ab,canada,faculty of medicine,university of calgary,calgary,ab,canada,sleep centre,foothills medical centre,calgary,ab, Canada, department of medicine,university of calgary,calgary,ab,canada,libin cardiovascular institute of alberta,university of calgary,calgary,ab,canada,faculty of medicine,university of calgary,calgary,ab, Canada, department of physiology and pharmacology,university of calgary,calgary,ab,canada,department of clinical neurosciences,university of calgary,calgary,ab,canada,hotchkiss brain institute,university of calgary,calgary,ab,canada,libin cardiovascular institute of alberta,university of calgary,calgary,ab,canada,faculty of medicine,university of calgary,calgary,ab,canada,faculty of kinesiology,university of calgary,calgary,ab, Canada
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|