|
|
|
|
Cost-effectiveness of clopidogrel-aspirin versus aspirin alone for acute transient ischemic attack and minor stroke
|
|
|
|
|
|
|
|
نویسنده
|
pan y. ,wang a. ,liu g. ,zhao x. ,meng x. ,zhao k. ,liu l. ,wang c. ,claiborne johnston s. ,wang y. ,wang y. ,wang y. ,johnston s.c. ,wang y. ,zhao x. ,wang z. ,xia h. ,li b. ,zhang g. ,ren x. ,ji c. ,zhang g. ,li j. ,lu b. ,wang l. ,feng s. ,wang d. ,tang w. ,li j. ,zhang h. ,li g. ,wang b. ,chen y. ,lian y. ,liu b. ,teng j. ,sui r. ,li l. ,yuan z. ,zang d. ,lu z. ,sun l. ,wang d. ,hou l. ,yuan d. ,cao y. ,li h. ,tan x. ,wang h. ,du h. ,liu m. ,wang s. ,liu q. ,zhang z. ,cui q. ,wang r. ,zhao j. ,zhang j. ,zhao j. ,bi q. ,qi x. ,liu j. ,li c. ,li l. ,pan x. ,zhang j. ,jiao d. ,han z. ,qian d. ,xiao j. ,xing y. ,du h. ,huang g. ,cui y. ,li y. ,feng l. ,gao l. ,xiao b. ,cao y. ,wu y. ,liu j. ,zhang z. ,dong z. ,wang l. ,he l. ,wang x. ,guo x. ,wang m. ,wang x. ,jiang j. ,zhao r. ,zhou s. ,hu h. ,he m. ,yu f. ,ouyang q. ,zhang j. ,xu a. ,qi x. ,wang l. ,shi f. ,guo f. ,wang j. ,zhao f. ,dou r. ,wei d. ,meng q. ,xia y. ,wang s. ,xue z. ,xu y. ,ma l. ,wang c. ,wu j. ,du y. ,wang y. ,xiao l. ,song f. ,hu w. ,chen z. ,liu q. ,zhang j. ,chen m. ,yuan x. ,liu z. ,li g. ,li x. ,tian t.
|
|
منبع
|
journal of the american heart association - 2014 - دوره : 3 - شماره : 3
|
|
چکیده
|
Background: treatment with the combination of clopidogrel and aspirin taken soon after a transient ischemic attack (tia) or minor stroke was shown to reduce the 90-day risk of stroke in a large trial in china,but the cost-effectiveness is unknown. this study sought to estimate the cost-effectiveness of the clopidogrel-aspirin regimen for acute tia or minor stroke. methods and results: a markov model was created to determine the cost-effectiveness of treatment of acute tia or minor stroke patients with clopidogrel-aspirin compared with aspirin alone. inputs for the model were obtained from clinical trial data,claims databases,and the published literature. the main outcome measure was cost per quality-adjusted life-years (qalys) gained. oneway and multivariable probabilistic sensitivity analyses were performed to test the robustness of the findings. compared with aspirin alone,clopidogrel-aspirin resulted in a lifetime gain of 0.037 qalys at an additional cost of cny 1250 (us$ 192),yielding an incremental cost-effectiveness ratio of cny 33 800 (us$ 5200) per qaly gained. probabilistic sensitivity analysis showed that clopidogrel-aspirin therapy was more cost-effective in 95.7% of the simulations at a willingness-to-pay threshold recommended by the world health organization of cny 105 000 (us$ 16 200) per qaly. conclusions: early 90-day clopidogrel-aspirin regimen for acute tia or minor stroke is highly cost-effective in china. although clopidogrel is generic,plavix is brand in china. if plavix were generic,treatment with clopidogrel-aspirin would have been cost saving. © 2014 the authors.
|
|
کلیدواژه
|
Clopidogrel; Cost-effectiveness; Quality-adjusted life-year; Stroke
|
|
آدرس
|
department of neurology,beijing tiantan hospital,capital medical university,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing, China, china national health development research center,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing, China, departments of neurology and epidemiology,university of california,san francisco,california, United States, department of neurology,beijing tiantan hospital,capital medical university,beijing, China, department of neurology,beijing tiantan hospital,capital medical university,beijing, China, beijing tiantan hospital, China, departments of neurology and epidemiology,university of california,san francisco, United States, beijing tiantan hospital, China, beijing tiantan hospital, China, taizhou first people's hospital, China, taiyuan iron and steel (group) co.,ltd.,general hospital, China, dagang oilfield gengeal hospital, China, penglai people's hospital, China, the third people's hospital of datong, China, the fourth central hospital of tianjin, China, the second hospital of hebei medical university, China, the first hospital of fangshan district,beijing, China, beijing puren hospital, China, tianjin ninghe district hospital, China, the people's hospital of zhengzhou, China, affiliated hospital of north china coal medical college, China, zhejiang zhoushan hospital, China, han dan central hospital, China, zhecheng people's hospital, China, shanxi medical university second hospital, China, baotou central hospital, China, the general hospital of changjiang river shipping, China, dalian economic and technological development zone hospital, China, first neurology department,affiliated hospital of north china coal medical college, China, the first affiliated hospital of zhengzhou university, China, first affiliated hospital of liaoning medical, China, lianyungang municipal hospital of tcm, China, central hospital in qiu county, China, tianjin first center hospital, China, renmin hospital of wuhan university, China, qingdao central hospital, China, baogang hospital, China, changzhi city people's hospital of shanxi province, China, ha lixun international peace hospital, China, people's hospital of linzi district,zibo, China, yantai city yantai mountain hospital, China, beijing pinggu district hospital, China, taiyuan central hospital, China, chengde central hospital, China, shijiazhuang central hospital, China, first neurology department,dalian municipal central hospital, China, xian 141 hospital, China, chengdu third municipal people's hospital, China, affiliated hospital of chifeng university, China, zhengzhou central hospital, China, ningbo city,zhejiang province lihuili hospital medical center, China, henan provincial people's hospital, China, jinzhong city second hospital, China, beijing anzhen hospital,capital medical university, China, beijing huairou district chinese medicine hospital, China, hebei medical university third hospital, China, first affiliated hospital shanxi medical unversity, China, hebei provincial people's hospital, China, guangzhou first municipal peoples hospital, China, central hospital in cangzhou, China, the chinese people's armed police force medical school affiliated hospital, China, zhejiang wenzhou medical college first affiliated hospital, China, jilin central hospital, China, anhui maanshan central hospital, China, beijing aviation industry central hospital, China, luhe hospital,tongzhou district,beijing, China, beijing fuxing hospital,capital medical university, China, the 306th hospital of p.l.a, China, the first affiliated hospital of tianjin university of chinese medicine, China, baiqiuen international peace hospital of people's liberation army, China, fourth affiliated hospital of china medical university, China, xiangya hospital central-south university, China, tangshan worker's hospital, China, the 1st hospital in handan, China, yangquan coal (group) co.,ltd.,general hospital, China, tianjin tianhe hospital, China, nantong first people's hospital, China, the 1st hospital of zhangjiakou city, China, west china hospital,sichuan university, China, the second affiliated hospital of shandong university of tcm, China, fenyang hospital of shanxi province, China, zhejiang zhoushan putuo district people's hospital, China, xiyuan hospital of china academy of chinese traditional medicine, China, no.2 people's hospital east in lianyungang city, China, affiliated hospital of qingdao university medical college, China, qilu hospital of shandong university, China, zibo hospital of traditional chinese medicine, China, beijing shijitan hospital, China, beijing haidian hospital, China, beijing shunyi district hospital, China, dalian third municipal hospital, China, the first affliated hospital of jinan university, China, navy genaral hospital of p.l.a, China, beijing second artillery general hospital, China, beijing daxing district hospital, China, sichuan province people's hospital, China, dalian municipal central hospital, China, the second hospital in baoding, China, the hospital combine traditional chinese and western medicine in cang zhou, China, the 309th hospital of p.l.a, China, liangxiang hospital of fangshan district,beijing, China, hua xin hospital first hospital of tsinghua university, China, tianjin huanhu hospital, China, shijiazhuang first hospital, China, the first affiliated hospital of zhengzhou university, China, xinzhou city people's hospital, China, sichuan province people's hospital of deyang city, China, first hospital,jilin university, China, shandong provincial hospital, China, fujian province hospital, China, liaoyang city third people's hospital, China, handan city center hospital, China, beijing chaoyang hospital,capital medical university, China, beijing university of chinese medicine east hospital, China, hebei medical university fourth hospital, China, the fourth affiliated hospital of soochow university, China, zhejiang university of chinese medicine affiliated first hospital, China, affiliated hospital of kailuan company ltd, China, affiliated hospital of weifang medical university, China, the first hospital of harbin medical university, China, dalian friendship hospital, China, tianjin dagang hospital, China
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|