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Blood lipids and the incidence of atrial fibrillation: the multi-ethnic study of atherosclerosis and the framingham heart study
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نویسنده
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alonso a. ,yin x. ,roetker n.s. ,magnani j.w. ,kronmal r.a. ,ellinor p.t. ,chen l.y. ,lubitz s.a. ,mcclelland r.l. ,mcmanus d.d. ,soliman e.z. ,huxley r.r. ,nazarian s. ,szklo m. ,heckbert s.r. ,benjamin e.j.
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منبع
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journal of the american heart association - 2014 - دوره : 3 - شماره : 5
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چکیده
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Background-dyslipidemia is a major contributor to the development of atherosclerosis and coronary disease. its role in the etiology of atrial fibrillation (af) is uncertain. methods and results-we studied 7142 men and women from the multi-ethnic study of atherosclerosis (mesa) and the framingham heart study who did not have prevalent af at baseline and were not on lipid-lowering medications. total cholesterol,high-density lipoprotein and low-density lipoprotein cholesterol,and triglycerides were measured using standard procedures. incident af during follow-up was identified from hospital discharge codes; review of medical charts; study electrocardiograms; and,in mesa only,medicare claims. multivariable cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals of af by clinical categories of blood lipids in each cohort. study-specific results were meta-analyzed using inverse of variance weighting. during 9.6 years of mean follow-up,480 af cases were identified. in a combined analysis of multivariable-adjusted results from both cohorts,high levels of high-density lipoprotein cholesterol were associated with lower af risk (hazard ratio 0.64,95% ci 0.48 to 0.87 in those with levels ≥60 mg/dl versus <40 mg/dl),whereas high triglycerides were associated with higher risk of af (hazard ratio 1.60,95% ci 1.25 to 2.05 in those with levels ≥200 mg/dl versus <150 mg/dl). total cholesterol and low-density lipoprotein cholesterol were not associated with the risk of af. conclusion-in these 2 community-based cohorts,high-density lipoprotein cholesterol and triglycerides but not low-density lipoprotein cholesterol or total cholesterol were associated with the risk of af,accounting for other cardiometabolic risk factors. © 2014 the authors. published on behalf of the american heart association,inc.,by wiley blackwell.
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کلیدواژه
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Atrial fibrillation; Cholesterol; Epidemiology; Lipids; Risk factors
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آدرس
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division of epidemiology and community health,school of public health,university of minnesota,minneapolis,mn, United States, departments of biostatistics,boston university,boston,ma,united states,nhlbi and boston university's framingham heart study,framingham,ma, United States, division of epidemiology and community health,school of public health,university of minnesota,minneapolis,mn, United States, section of cardiovascular medicine,departments of medicine,boston,ma,united states,nhlbi and boston university's framingham heart study,framingham,ma, United States, departments of biostatistics,university of washington,seattle,wa, United States, cardiovascular research center,massachusetts general hospital,charlestown,ma,united states,cardiac arrhythmia service,massachusetts general hospital,boston,ma, United States, cardiovascular division,department of medicine,university of minnesota medical school,minneapolis,mn, United States, cardiovascular research center,massachusetts general hospital,charlestown,ma,united states,cardiac arrhythmia service,massachusetts general hospital,boston,ma, United States, departments of biostatistics,university of washington,seattle,wa, United States, nhlbi and boston university's framingham heart study,framingham,ma,united states,cardiology division,department of medicine,university of massachusetts medical school,worcester,ma, United States, epidemiological cardiology research center,department of epidemiology and prevention,wake forest school of medicine,winston salem,nc, United States, school of population health,university of queensland,brisbane,qld, Australia, department of cardiology/medicine,johns hopkins university,baltimore,md,united states,department of epidemiology,johns hopkins bloomberg school of public health,baltimore,md, United States, department of epidemiology,johns hopkins bloomberg school of public health,baltimore,md, United States, departments of epidemiology,university of washington,seattle,wa, United States, section of cardiovascular medicine,departments of medicine,boston,ma,united states,nhlbi and boston university's framingham heart study,framingham,ma,united states,department of epidemiology,boston university school of public health,boston,ma, United States
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Authors
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