effect of vitamin c on coagulation factors and endothelium function in patients with sepsis

Objective: sepsis is one of the leading causes of mortality in intensive care unit. despite advances in its management, its mortality rate remains high. recently, high dose of vitamin c in sepsis treatment has attracted the attention of researchers. in the current study, the impacts of 25 mg/kg of vitamin c every 6 hours as a bolus for 3 days were assessed in septic patients in intensive care unit (icu). methods: this was a prospective cohort study that was performed on adult patients with diagnosis of sepsis. patients were assigned to control group (administration of placebo) or intervention group, i.e., those receiving a 25 mg/kg dose of vitamin c every 6 hours as a bolus for 3 days. clinical data were recorded before and after the experiment. also, plasma levels of antithrombin iii, syndecan-1, fibrin degradation product (fdp), d-dimer, and c-reactive protein (crp) were measured at 0, 24, 48, and 72 hours. results: in septic patients receiving vitamin c, a significant upregulation of antithrombin iii and significant decreases in the levels of syndecan-1 (at 48 hours; p-value=0.046 and at 72 hours; p-value=0.007), d-dimer and crp were observed compared to the control. reductions in sequential organ failure assessment (sofa) score, in-hospital mortality, and icu length of stay were seen in septic patients receiving vitamin c. conclusion: prescribing high dose of intravenous vitamin c can reduce the mortality of sepsis patients and reduce the length of stay in the icu.