potential therapeutic approaches in paraquat poisoning: a narrative review

Paraquat dichloride (pq) poisoning is a relatively rare yet critical medical condition that has a high case fatalityrate. lung tissue is highly susceptible to pq-induced injury, and respiratory failure is the leading cause of deathin these patients. unfortunately, there is a lack of an effective therapeutic approach to ameliorate outcomes. itis well-known that pq interferes with a variety of cell signaling pathways and induces the generation of reactiveoxygen species (ros), which ultimately results in cell injury. the traditional treatment decisions have not beenable to significantly change the clinical course of pq poisoning. moreover, novel therapeutic strategies for pqpoisoning have centered on the inhibition of pq-induced signaling pathways. in the current review, we soughtto provide a bird’s-eye view of the available therapeutic approaches in patients with pq poisoning.