the relationship between the results of coagulation profile and severity of pulmonary involvement in covid-19 patients

Introduction: covid-19 is currently a global pandemic, and coagulation-related mortality has been widely reported in patients suffering from it.objective: this article aimed to investigate the coagulation profile of covid-19 patients. methods: this was a cross-sectional study conducted using a retrospective research design. we recruited patients with covid-19 admitted to a hospital from june 15th to july 7th, 2020. upon patients’ entering a blood sample was drawn from each patient for assessing patient’s coagulation profile (pt, ptt, inr, platelet count); and a chest high-resolution computed tomography (hrct) scan was performed for each patient. the study patients were divided in to sever group (co-rads score 5) and non-sever group (co-rads score <5).results: thirty-six patients (20 males and 16 females) with a mean age of 54.7±17.5 years were studied. of them, 11 cases (30.56%) had severe pulmonary involvement. also, the coagulation profiles were longer in the severe group than non-sever group. as well, the means of platelet count that were 232.440 per microliter in the non-severe group and 289.180 per microliter in the severe and non-sever groups, respectively; but still not statistically significant (p>0.05). the area under the roc curve (auc) for pt and inr was 0.615 and 0.611, respectively. the auc for platelet count was 0.680 (95% ci: 0.501 to 0.859) and had an acceptable discriminating power.conclusions: in this study, we did not find any statistically significant relationship between the results of coagulation tests and the severity of pulmonary involvement according to hrct scan findings in covid-19 patients. but further analyses suggest that, except ptt, the other coagulation tests (pt, inr, and platelet count) may discriminate severe covid-19 patients.