the relationship between premature myocardial infarction with tc/hdl-c ratio subgroups in a multiple risk factor model

Introduction: so far, there is no evidence available to demonstrate the relationship between five subgroups of total cholesterol/high density lipoprotein cholesterol (tc/hdl-c) ratio with premature myocardial infarction (mi).objective: we conducted a case control study to probe more features of the relation between tc/hdl-c ratio and the five subgroups of the ratio with myocardial infarction under 55 years and above it.method: a hospital based case control study with incident cases was designed. cases and controls were comprised of 523 under 55-year and 699 above 55-year documented newly diagnosed mi cases, respectively. standardized clinical and para clinical method were used to ascertain disease and risk factors. independent sample t-test, pearson chi square test, odds ratios and mantel-haenszel test and logistic regression analysis conducted to evaluate relationships.results: this study enrolled 1222 mi cases. patients with very low risk category of tc/hdl-c ratio estimated or=0.18 with 95% confidence interval (ci) (0.04-0.72) for developing mi under 55 years. patients who had low risk category of tc/hdl-c ratio having or=0.26 95% ci (0.07-0.89). low risk and very low risk categories of the tc/hdl-c ratio compare to high risk subgroup of the ratio demonstrate decreased risk of developing mi under 55 years p<0.05.conclusion: our study results can be translated as an aggressive treatment for lowering tc/hdl-c ratio in both general population and victims of coronary events. mitigation of the level of tc/hdl-c ratio from low risk to very low risk category will attenuate the risk of mi under55 years about 8% which is the immediate clinical implication of our findings.