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Evaluation and Comparison of the Toxicity of Some Iranian Native Plants and Microalgae, Using Brine Shrimp Test (BST)
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نویسنده
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jafari shima ,mobasher nazanin ,ghasemi younes ,museli samira ,bidad sajjad ,mobasher mohammad ali
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منبع
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trends in pharmaceutical sciences - 2016 - دوره : 2 - شماره : 4 - صفحه:285 -290
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چکیده
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Brine shrimp lethality test is a useful and appropriate method for toxicity identification of compounds in plants. moreover, artemia spp. are among the most common salt water organisms worldwide, which can be used in this kind of experiments. many plants are being used for treatment of variable diseases and have many applications in pharmaceuticals and medicine. however, some of them have toxic components that limit their use and can create some risks for consumers. this study investigated the toxicity of two kinds of microalgae and three kinds of plants against larvae of artemia urmiana (a. urmiana). this study aimed to evaluate the toxicity degree of active metabolites in some plants and microalgae against a. urmiana nauplii as a standard toxicity evaluating method. after 48 h of incubation, newly hatched artemia nauplii were exposed to different concentrations of herbal extracts. brine shrimp lethality test was used for investigation of samples toxicity in different doses between 100 to1000 μg/ml in time intervals. results showed that these herbal extracts have high potential larvicidal properties on a. urmiana. ephedra intermedia had the maximum and dunaliella salina showed the minimum effects on mortality. the achieved results indicated that there were straight correlation between dose of extracts and mortality of brine shrimp nauplii. the potential toxicity of extracts was as follows: e.intermedia>c.procera>o.persica>c.vulgaris>d.salina.
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کلیدواژه
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Artemia Salina ,Brine Shrimp ,Lethality Assay ,Toxicity Test
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آدرس
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fasa university of medical sciences, noncommunicable diseases research center, school of medicine, department of medical biotechnology, ایران. payame noor university, department of agricultural biotechnology, ایران, shiraz university of medical sciences, school of medicine, department of biochemistry, ایران, shiraz university of medical sciences, school of pharmacy, pharmaceutical sciences research center, department of pharmaceutical biotechnology, ایران, fasa university of medical sciences, school of medicine, noncommunicable diseases research center, department of medical biotechnology, ایران, fasa university of medical sciences, school of medicine, noncommunicable diseases research center, department of medical biotechnology, ایران, fasa university of medical sciences, school of medicine, noncommunicable diseases research center, department of medical biotechnology, ایران
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Authors
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