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Synthesis and Biological Evaluation of Metronidazole Derivatives As Anti- Giardia Agents
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نویسنده
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Shahriari Bahador ,Rezaei Zahra ,Khabnadideh Soghra ,Sadeghpour Hossein ,Hatam Gholam Reza ,Asgari Qasem ,Kiani Amin ,Firoozi Fardad
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منبع
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Trends In Pharmaceutical Sciences - 2015 - دوره : 1 - شماره : 2 - صفحه:105 -110
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چکیده
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Nitroimidazole derivatives such as metronidazole (mtz) have been used as anti- protozoa and anti-anaerobic bacteria. in this study several derivatives of mtz were synthesized and evaluated against giardia lamblia cyst. mtz were reacted with several alkyl halide to obtain o-alkyl mtz derivatives, then products were purified and their chemical structures were confirmed by spectral analysis (1hnmr and mass). in order to assess biological evaluation, all compounds were investigated against 25 giardia samples isolated from giardia-infected patients. results showed that compound 2 had the most activity on cyst of giardia in comparison with mtz.
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کلیدواژه
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Nitromidazole ,Metronidazole Derivatives ,Antigiarida
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آدرس
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Shiraz University Of Medical Sciences, Basic Sciences In Infectious Diseases Research Center, ایران, Shiraz University Of Medical Sciences, Pharmaceutical Sciences Research Center, School Of Pharmacy, Department Of Medicinal Chemistry, ایران, Shiraz University Of Medical Sciences, Pharmaceutical Sciences Research Center, School Of Pharmacy, Department Of Medicinal Chemistry, ایران, Shiraz University Of Medical Sciences, School Of Pharmacy, Pharmaceutical Sciences Research Center, Department Of Medicinal Chemistry, ایران, Shiraz University Of Medical Sciences, School Of Medicine, Department Of Parasitology And Mycology, ایران, Shiraz University Of Medical Sciences, School Of Medicine, Department Of Parasitology And Mycology, ایران, Shiraz University Of Medical Sciences, Pharmaceutical Sciences Research Center, School Of Pharmacy, Department Of Medicinal Chemistry, ایران, Shiraz University Of Medical Sciences, Pharmaceutical Sciences Research Center, School Of Pharmacy, Department Of Medicinal Chemistry, ایران
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Authors
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