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   triple therapy with garlic, silymarin and curcumin in non alcoholic fatty liver disease: a randomized, placebo controlled clinical trial  
   
نویسنده rahimi hamid reza ,mosanan mozaffari hooman ,mazloumi kiapey shabnam ,vahabzadeh maryam ,ziaee maliheh ,ataee zahra
منبع herbal medicines journal - 2021 - دوره : 6 - شماره : 2 - صفحه:50 -64
چکیده    Background and aim: non-alcoholic fatty liver disease (nafld) is the most common liver disease in the world. we aimed to evaluate the effect of a mixture of garlic, silymarin, and curcumin on hepatic parameters and overall improvement of nafld. materials and methods: individuals between 18 and 70 years of age with altered liver enzymes and confirmed pattern of fatty liver in their hepatic ultrasound were entered into this randomized, triple-blind, placebo-controlled trial and assigned to two groups. they received either capsules containing curcumin, silymarin and garlic or an identical placebo. after 3 months, the patients were re-evaluated for laboratory tests, clinical evaluation, and liver fibroscan. data were analyzed in consistent with the intention-to-treat approach. results: after randomization and blinding, 50 individuals entered this study. the mean age of the participants was 42.51 ± 11.13 (mean± sd) years of old, and 80% of the participants were men. after triple therapy, no significant differences were observed in laboratory tests between the two groups, except for the triglyceride level (188.86 ± 90.66 vs. 146.23 ± 70.38, p-value=0.04). however, hepatic fibroscans were noticeably ameliorated in the treatment group compared to the control (p-value <0.001). conclusion: we observed no significant amelioration in the majority of biochemical indices of the patients, but patterns of nafld in fibroscans were considerably improved. although we cannot entirely attribute this finding to our therapy with silymarin, curcumin, and garlic, a healthy lifestyle combined with these supplements can help improve the state of nafld. further studies with larger sample size and different doses are recommended.
کلیدواژه nafld ,garlic ,silymarin ,curcumin ,liver
آدرس mashhad university of medical sciences, vascular and endovascular surgery research center, department of medical genetics and molecular medicine, iran, mashhad university of medical sciences, faculty of medicine, gastroenterology and hepatology department, iran, mashhad university of medical sciences, faculty of medicine, department of nutrition science, iran, mashhad university of medical sciences, medical toxicology research center, iran, gonabad university of medical sciences, school of medicine, social determinants of health research center, department of community medicine, iran, mashhad university of medical sciences, school of medicine, department of internal medicine, iran
 
     
   
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