>
Fa   |   Ar   |   En
   evaluation of the phytochemistry and antidepressantlike effect of cinnamomum verum essential oil in male mice  
   
نویسنده moslem-zadeh tannaz ,abbasi-maleki * saeid ,sadeghi-hashjin goudarz
منبع herbal medicines journal - 2019 - دوره : 4 - شماره : 3 - صفحه:119 -126
چکیده    Background and aim: previous studies have reported the antioxidant, analgesic, antiinflammatory, and neuroprotective effects of cinnamomum verum (cv). hence, the phytochemistry and antidepressantlike effects of the cv essential oil were investigated in the present study by the forced swimming test (fst) and tail suspension test (tst) in male mice.materials and methods: seventytwo male nmri mice (2030 g) were randomly divided into the control or vehicle (10 ml/kg, i.p.), the fluoxetine (20mg/kg, i.p.), the imipramine (30mg/kg, i.p.), and the cv essential oil (5, 10 & 20 mg/kg, i.p.) groups. the immobility, swimming, and climbing times of the mice in fst, as well as the immobility time in tst were determined and recorded.results: based on the gcms analysis, the main component was cinnamaldehyde (87.42%). furthermore, all doses of the cv essential oil decreased immobility times in fst (p< 0.001 and p<0.05, respectively) and tst (p<0.001). moreover, all doses of the essential oil increased swimming time (p< 0.01 and p<0.001), but the climbing time was only increased by 10 and 20 mg/kg of the essential oil (p< 0.01 and p<0.001, respectively).conclusion: according to the findings of the present study, the major components of the cv essential oil (e.g. cinnamaldehyde) are likely to have antidepressant effects due to its monoaminergic mechanism. nevertheless, further studies are required to determine its exact mechanism of action.
کلیدواژه antidepressant ,cinnamomum verum ,forced swimming test ,tail suspension test ,monoaminergic system ,mice
آدرس islamic azad university, urmia branch, department of pharmacology & toxicology, iran, islamic azad university, urmia branch, department of pharmacology & toxicology, iran, university of tehran, faculty of veterinary medicine, iran
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved