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   A Comparison of the Anxiolytic and Hypnotic Effects of Origanum Majorana Essential Oil and Alprazolam in Male Mice  
   
نویسنده Manouchehri Neghin ,Abbasi-Maleki Saeid ,Mousavi Zahra
منبع Herbal Medicines Journal - 2019 - دوره : 4 - شماره : 1 - صفحه:18 -26
چکیده    Background and aim: previous studies have reported many pharmacological properties for origanum majorana, including anticonvulsant, analgesic, sedative, and antidepressantlike effects. given this, the aim of this study was to compare the anxiolytic and hypnotic effects of origanum majorana essential oil (omeo) and alprazolam in male mice.material and methods: in this experimental study, 60 male nmri mice were divided into 10 groups of six each. in both of the experiments, negative control groups received vehicle (10 ml/kg) and positive control groups received alprazolam (0.5 mg/kg) and treatment groups received omeo (10, 20 and 40 mg/kg). for assessing anxiolytic effects, the number of entries and the time spent in the open and closed arms were recorded by using elevated plus maze (epm). for evaluating hypnotic effects, the onset and duration of the sleep were recorded by using ketamineinduced sleeping time test. oneway anova followed by post hoc tukey's test were used for statistical analysis.results: all doses of omeo and alprazolam, compared to control group, increased the number of entries and the time spent in the open arms and, conversely, reduced the number of entries and the time spent in the closed arms. in addition, all   doses of the essential oil similar to alprazolam reduced the onset of sleeping and increased the duration of sleep.conclusion:  the results relieved that the omeo have anxiolytic and hypnotic effects. however, further studies are needed to determine their exact mechanism of action.
کلیدواژه Origanum Majorana ,Anxiety ,Hypnotic Effect ,Elevated Plus Maze ,Mice
آدرس Islamic Azad University, Tehran Medical Sciences, Faculty Of Pharmacy And Pharmaceutical Sciences, Iran, Islamic Azad University, Urmia Branch, Department Of Pharmacology & Toxicology, Iran, Islamic Azad University, Tehran Medical Sciences, Faculty Of Pharmacy And Pharmaceutical Sciences, Department Of Pharmacology And Toxicology, Iran
 
 

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