>
Fa   |   Ar   |   En
   Evaluation of Effectiveness of Ethanolic Extract of Curcuma Longa, Discretely and in Combination With Chloroquine Against Chloroquine-Sensitive Strain of Plasmodium Berghei  
   
نویسنده Heydarian Peyman ,Nateghpour Mehdi ,Mazhari Nahideh ,Motevalli Haghi Afsaneh ,Farivar Leila ,Souri Effat ,Javadi Mamaghani Amirreza ,Rahimi Esboei Bahman
منبع Herbal Medicines Journal - 2018 - دوره : 3 - شماره : 4 - صفحه:133 -138
چکیده    Background and aim: malaria is a parasitic disease and one of the most important public health problem. chemical medications such as chloroquine, primaquine, pyrimethamine, mefloquine, artemisinin and fansidar are commonly used to treat malaria but most of the antimalarials have encountered with problem of drug resistance. therefore, new therapeutic materials are promptly needed. during many years natural medicines, especially medicinal plants have been considered as the pivotal means for treatment of malaria in some endemic areas. in this study, we evaluated the effectiveness of ethanolic extract of curcuma longa l, discretely and in combination with chloroquine against chloroquine-sensitive strain of plasmodium berghei. materials and methods: fifty percent effective dose (ed50s) of c. longa and chloroquine were determined according to peter̛ s method. then based on the obtained ed50s combination of curcuma longa and chloroquine with different ratios were examined against the strain. results: the results of ed50s for chloroquine and c. longa were 1.4mg/kg and 1250mg/kg, respectively. combination of c. longa ethanolic extract with chloroquine in ratio of 80/20 showed the highest activity with 71.75% to inhibit the growth of p. berghei indicating synergistic interaction in the combination treatment. conclusion: it appears that turmeric (c. longa) extract is an effective anti-malarial substance especially in combination with chloroquine.
کلیدواژه Turmeric Extract ,Plasmodium Berghei ,Interaction ,Chloroquine
آدرس Tehran University Of Medical Sciences, Scientific Research Center, Iran. University Of Medical Sciences, School Of Medicine, Department Of Medical Parasitology And Mycology2 Department Of Medical Parasitology And Mycology, Iran, Tehran University Of Medical Sciences, School Of Public Health, Research Center Of Quran Hadith And Medicine, Department Of Medical Parasitology And Mycology, Iran, Tehran University Of Medical Sciences, School Of Public Health, Department Of Medical Parasitology And Mycology, Iran, Tehran University Of Medical Sciences, School Of Public Health, Department Of Medical Parasitology And Mycology, Iran, Tehran University Of Medical Sciences, School Of Public Health, Department Of Medical Parasitology And Mycology, Iran, Tehran University Of Medical Sciences, Faculty Of Pharmacy, Department Of Pharmaceutical Chemical, Iran, Shahid Beheshti University Of Medical Sciences, School Of Medicine, Department Of Parasitology, Iran, Tehran University Of Medical Sciences, School Of Public Health, Department Of Medical Parasitology And Mycology, Iran
 
 

Copyright 2015
Islamic World Science Citation Center
All Rights Reserved