the effects of olive leaf extract administration on the cerebral hypoperfusion-induced electrophysiological alterations in rat heart

Background and aim: in the present study, the role of ethanolic extract of olive (olea europaea) leaf administration against the cerebral hypoperfusion-induced electrophysiological alterations and left ventricular thickness in rat heart was studied.materials and methods: the right carotid artery was occluded with a 50 silk suture and the left carotid artery was occluded after a week. the olive (olea europaea) leaf extract was administered orally (by gavage) to three experimental groups of rats in 100, 200 and 300 mg/kg/day for two weeks after the left carotid artery occlusion and processed in 25 days. the sham and hypoperfusion groups were fed with normal saline. each group had 6 rats. after 25 days, electrophysiological heart parameters, i.e. hr, qtc, qrs duration, qt interval, pr interval, rr interval, st amplitude, t wave amplitude and also the thickness of left ventricle (tlv) were assessed.results: the administration of olive leaf extract (100, 200 and 300 mg/kg) exhibited its cardioprotective effect by both stabilizing heart rate and preventing ecg changes (such as shortening of pr, qrs, qt and qtc intervals, prominent t waves and st elevation). moreover, olive leaf extract (100, 200 and 300 mg/kg) prevented cardiac hypertrophy after cerebral hypoperfusion.conclusion: our results indicated that posttreatment with ethanolic extract of olive leaves could prove beneficial effects in managing the cerebral hypoperfusion-induced cardiac abnormality in rats.