numerical simulation of the bubble dynamics inside an enclosure containing blood under the influence of pressure oscillations

This study investigates the evolution of bubble shape within a square area filled with blood. the accuracy of the numerical solution is validated using laplace’s problem and the free-rising of the bubble. the analysis is conducted in two dimensions and in a transient manner. the effects of ultrasound waves are applied as a function of pressure on the boundaries of the solution domain. results show that applying a linearly increasing pressure on the computational domain boundaries causes a reduction in bubble radius. furthermore, it is observed that assuming the air inside the bubble behaves as an ideal gas, leads to more pronounced changes in bubble radius compared to constant density assumptions. oscillatory pressure distributions on the external boundaries result in corresponding oscillations in bubble radius. these fluctuations in bubble size could be utilized to exert tension on the walls of blood clots, ultimately aiding in their dissolution. the most intensive bubble size fluctuations occur in the frequency of 1 (mhz). additionally, the disproportionate changes in bubble radius with pressure variations are attributed to the hysteresis phenomenon.