selenium supplementation in psoriasis patients

Psoriasis is an autoimmune skin disease known for inflammation and hyper-proliferation of epidermal keratinocytes (luo et al., 2020). 2-3% of the population suffer from psoriasis (parisi et al., 2013). emotional distress in psoriasis patients impairs quality of their life. moreover, they suffer from the burden of comorbidities like obesity, diabetes mellitus, metabolic syndrome (armstrong et al., 2013b), and hypertension (armstrong et al., 2013a) through the increase in psoriasis severity. the pathogenesis of psoriasis is not well understood yet. it is concluded from the interactions between genetic predisposition and the environmental risk factors, such as diet, alcohol consumption, stress, obesity, and smoking (ricketts et al., 2010). one pathogenesis of psoriasis is amplifying t-cells and dendritic cells from the immune system, which releases various pro-inflammatory cytokines and chemokines with simultaneous activation of growth factors (al-harbi et al., 2020). moreover, oxidative stress and reactive oxygen species (ros) production causes inflammation (wacewicz et al., 2017). high free radicals have harmful effects through structural changes on proteins, lipids, and nucleic acids. the increase in oxidants leads to active antioxidant defense mechanisms (lobo et al., 2010). corresponding author:azadeh lesaniview orcid in profileyou can search for this author in pubmed     google scholar profile