the effect of superparamagnetic fe3o4 nanoparticles combined with quercetin on breast cancer cell line (mcf-7)

Background: magnetic nanoparticles attract increasing interest due to their use in cancer therapy and as drug carriers for several other diseases. the present study investigates the physiochemical properties of quercetin-conjugated superparamagnetic fe3o4 nanoparticles and their effects on breast cancer cell line mcf-7. methods: a simple precipitation method was used to prepare the poly ethylene imine (pei)-coated fe3o4 nanoparticles; they were then conjugated with flavonoid-compound quercetin on the surface via carboxylic/amine group using nanoprecipitation method. then, the physical and chemical parameters were calculated using zeta-sizer, scanning electron microscopy (sem), and extract release patterns at 37 and 42 0c. finally, the toxicity level of this quercetin- conjugated nanosystem on the mcf-7 cells was investigated by mtt assay. results: the results showed that the prepared nanosystem attained about 74% of quercetin inclusion, 91.2 nm size, 65.1 mv zeta potential, spherical morphology and a controlled release. compared to fe3o4 nanoparticles and pure quercetin, mtt and microscopy analysis revealed that quercetin-conjugated fe3o4 nanoparticles induced considerable cytotoxicity, and morphology changes against mcf7 cells. conclusion: quercetin-conjugated fe3o4 nanoparticles have appropriate physiochemical properties; they can be a suitable carrier for drug delivery and a promising therapy for candidates.corresponding author:bibi fatemeh haghiralsadatview orcid in profile you can search for this author in pubmed  google scholar profile