the association between saliva and serum vitamin d with knee osteoarthritis

Background: the incidence of osteoarthritis (oa) is high in patients suffering from 25-hydroxyvitamin d3 (25(oh)d) deficiency. the goal of this study is to examine the association between saliva and serum 25(oh)d and knee oa. methods: serum and saliva 25(oh)d levels of 30 patients with knee oa and 30 matched healthy people in a control group were measured by elisa. knee pain was assessed by western ontario and mcmaster universities arthritis index (womac). data were analyzed through student’s t-test, pearson correlation test and receiver operating characteristic (roc). results: the mean serum and saliva 25(oh)d levels were lower in knee oa group than the healthy group. womac negatively correlated with serum (r = -0.37; p = 0.02) and with unstimulated(r = -0.30; p = 0.04) saliva 25(oh)d. the unstimulated saliva 25(oh)d cutoff value was 27.8 pg/m1 regarding the diagnosis of knee oa. conclusion: serum 25(oh)d levels were positively associated with saliva 25(oh)d, and 25(oh)d level in saliva, as in serum, was low in knee oa.