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Hydrophilic Phytochelators in Iron Overload Condition
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نویسنده
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Sajadi Hezaveh Zohreh ,Shidfar Farzad
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منبع
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Journal Of Nutrition And Food Security - 2019 - دوره : 4 - شماره : 2 - صفحه:142 -151
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چکیده
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Background: iron overload can cause many complications and damage many organs as well as physiologic functions. consumption of phetochemicals and flavonoids with iron chelating ability, instead of synthetic iron chelators, can be less harmful and more effective. the aim of this review is to investigate hydrophilic phytochelators in iron overload condition. methods: in this review, the possible natural iron chelators including quercetin, rutin, bailcalin, silymarin, resveratrol, mimosine, tropolone, curcumine, catechin, kojic acid, and caffeic acid were investigated. furthermore, the mechanisms through which they chelate iron were discussed. results: the mentioned antioxidants eliminated excessive iron, decreased iron absorption, exerted antioxidant and anti-inflammatory activity without causing adverse effects and other metal deficiencies in iron overload condition. conclusion: the combination of synthetic chelators with these antioxidants or their replacement with natural chelators could be possible treatments for iron overload.
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کلیدواژه
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Iron Overload ,Iron Chelation ,Iron Chelator ,Antioxidant ,Flavonoid ,Polyphenol
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آدرس
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Iran University Of Medical Sciences, School Of Public Health, Department Of Nutrition, ایران, Iran University Of Medical Sciences, School Of Public Health, Department Of Nutrition, ایران
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پست الکترونیکی
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farzadshidfar@yahoo.com
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Authors
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