determination of anti-cancer effects of poly (l,d-lactide-co-glycolide)-block-poly (ethylene glycol) nanocarrier loaded with naringenin

In this research, poly (dl-lactide-co-glycolide)-block-poly (ethylene glycol), (plga-peg) nanoparticles (nps) of less than 195 nm in diameter containing of naringenin (nrg) a naturally flavonoid were synthesized. encapsulated form nrg improves its medical properties and solubility. the therapeutic efficacy of the encapsulated naringenin (nrg-nps) and nrg on human lung epithelial (a549) and mouse mammary (4t1) carcinoma cells proliferation was determined by mtt assays. the cytotoxicity potency was rated as follows: nrg-nps > nrg. the antioxidant effects of the nrg and nrg-nps were also determined by frap method. our results show that nrg-nps are cytotoxic compounds for cancer cells and anti-cancer effect can be attributed to the presence of fe chelatory and antioxidant effects of nrg-nps.