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electroanalytical determination of isoniazid in pharmaceutical formulation and human plasma, using a poly(eriochrome black-t) modified pencil lead electrode
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نویسنده
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asadpour-zeynali karim ,arteshi yaser
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منبع
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iranian journal of analytical chemistry - 2017 - دوره : 4 - شماره : 1 - صفحه:51 -58
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چکیده
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In this research, an inexpensive and effective method for determination of isoniazid (inh) is presented by using a poly (eriochrome black t) modified pencil lead electrode. the potential of modified electrode in electrochemical sensing of inh was evaluated by cyclic voltammetry and hydrodynamic amperometry methods. the overall number of electrons involved in oxidation of inh was fond 4 electrons. the calculate diffusion coefficient for inh was equal to 9.74 × 107 cm2/s. calculated limit of detection for method was 66.0µm and 20.4µm applying cyclic voltammetry and hydrodynamic amperometry methods, subsequently. the ability of prepared electrode for determination of inh in real sample was evaluated by applying the proposed method to human plasma analysis and the results were compared with the standard method, presented by united state pharmacopeia. presented method exhibited a satisfying precision (%rsd=4.64). also the proposed method showed a good accordance with standard method in confidence level of 95%.
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کلیدواژه
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isoniazid ,eriochrome blackt ,modified electrode ,determination
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آدرس
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university of tabriz, faculty of chemistry, department of analytical chemistry, ایران, university of tabriz, faculty of chemistry, department of analytical chemistry, ایران
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اندازه گیری الکتروشیمیایی ایزونیازید در فرمولاسیون های دارویی و سرم انسان با استفاده از الکترود مغز مداد اصلاح شده با پلی اریوکروم بلاک تی
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Authors
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اسد پور زینالی کریم ,ارتشی یاسر
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