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   indirect determination of anticancer drug capecitabine using hollow fiber supported multiwalled carbon nanotube coated on polyurethane foam  
   
نویسنده معین پور فاطمه ,اسحاقی زرین
منبع iranian journal of analytical chemistry - 2018 - دوره : 5 - شماره : 2 - صفحه:9 -16
چکیده    The aim of this work was indirect determination of anti-cancer drug capecitabine using complexation with platinum (iv) and determination by graphite furnace atomic absorption spectroscopy (gfaas). for this aim at first, the complex of platinum with capecitabine was performed and the ratio of drug to metal was evalutsd with several ways. in the all of these methods, the ligand to metal ratio of the potassium hexachloroplatinate (iv) and capecitabine complex was found to be 2:1. the extraction process was carried out by the hollow fiber supported functionalized multiwalled carbon nanotubes/ polyurethane foam (fmwcnt/puf) foam as the solid adsorbent in the solid phase microextraction mode. the amount of desorbed platinum ion has been indirectly used to measure the drug concentrations. parameters affecting the hollow fiber-solid phase microextraction (hf-spme) such as ph of the donor phase, donor phase volume, the sorbent type and desorption solvent were optimized. calibration graph was plotted and a curve with a linear response range of the 3.32 to 98.17 μg ml ^-1 and a detection limit 0.38 μg ml ^-1 was obtained
کلیدواژه capecitabine ,spe method ,indirect determination ,graphite furnace atomic absorption spectroscopy
آدرس payame noor university, department of chemistry, ایران, payame noor university, department of chemistry, ایران
پست الکترونیکی eshaghi@pnu.ac.ir
 
   ارزیابی غیر مستقیم داروی ضد سرطان کپسیتابین با استفاده از فیبر منخلخل حمایت شده با فوم پلی اورتان/ نانولوله های کربنی عاملدار  
   
Authors اسحاقی زرین
  
 
 

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