effects of vitamin d supplementation on inflammatory markers in multiple sclerosis patients: a systematic review and meta-analysis

Context: numerous studies have indicated that vitamin d can modulate the immune system and plays an important role in regulating immune cells’ functions. some clinical studies have assessed the effect of vitamin d supplementation on cytokine markers in multiple sclerosis (ms) as a disease in which the immune system’s function is disrupted. evidence acquisition: this study was designed to assess randomized clinical trial studies evaluating the overall effect of vitamin d on the levels of il-10, il-17, and ifn- in ms patients. methods:we searched pubmed and scopus online databases up to november 2020 for relevant randomized clinical trial studies by using certain keywords. eight studies from 273 articles, with a total sample of 443 participants, were considered results: the meta-analysis indicated that vitamin d consumption did not significantly change the levels of il-10 (wmd : -174.56, 95% ci: -373.10 to 23.98), il-17 (wmd : -0.11, 95% ci: - 0.54.10 to 0.33), or ifn- (wmd : 61.47, 95% ci: 43.96 to 78.98) in ms patients. conclusions: further clinical trials are warranted to evaluate the effects of vitamin d supplement on il-10 and il-17, and inf levels in ms patients.