Genetic Polymorphism of Thr241met and Other Risk Factors Related With Gastric Cancer in Iranian Military Population: A Pilot Case Control Study

Background: gastric cancer (gc) is a result of interaction between genetic and environmental factors. the recognition of gc risk factors is very important for early diagnostic and prevention from this cancer. objectives: the objective of this study was to investigate the effects of some factors such as thr241met polymorphism on gc occurrence in iranian military population. methods: investigated samples in the present study were 53 tissue samples from patients with pathologically proven gc and 91 sex-age matched blood samples from healthy controls. data for cases and controls were obtained through registered files and questionnaires, respectively. genomicdnawasextractedandpcr-rflpwasused for genotyping of thr241met polymorphism. chi-square and odds ratio (or) were used to determine the factors affecting the incidence of gc. results: the thrmet genotype of thr241met polymorphism of the xrcc3 gene (p = 0.04 and or = 2.99) and blood type b (p = 0.04 and or = 2.99) significantly affected the incidence of gc. this study did not prove the significant effect of smoking (p = 0.08 and or = 2.47) and positive family history (p = 0.13 and or = 2.25) on gc risk. conclusions: these findings may be helpful in early identification of high-risk individuals, especially in military population and prevention from gc.