The Effect of Endurance Training and Purslane Seed Consumption on Nf-Kb and Crp in the Heart Tissue of Rats Exposed To Oxidative Damage Induced By H2o2

Background: oxidative stress is a state of imbalance in capacity to neutralize the free radicals and its production. objectives: the present study aimed to investigate the effect of endurance training and purslane seed consumption on nf-κb and crp in the heart tissue of rats poisoned by h2 o2 . methods: sixty-four adult male rats were randomly assigned into eight groups of eight rats (1) control, (2) endurance training, (3) endurance training with 50 mg/kg/day supplementation of purslane seed, (4) endurance training with 200 mg/kg/day supplemen- tation of purslane seed, (5) endurance training with 400 mg/kg/day supplementation of purslane seed, (6) 50 mg/kg/day supplementation of purslane seed, (7) 200 mg/kg/day supplementation of purslane seed, and (8) 400 mg/kg/day supplementation of purslane seed. during eight weeks groups one through eight received 1 mmol/kg h2 o2 three times per week intraperitoneally; groups two through four ran on a treadmill three sessions per week, and groups two through eight received purslane seed intraperitoneally daily. two-way anova and the bonferroni post hoc tests were used for statistical data analysis (p ≤ 0.05). results: endurance training significantly increased crp protein levels (p = 0.001), however, the purslane seed consumption significantly reduced crp protein levels (p = 0.001), and endurance training with purslane seed extract consumption had interactive effects on reduction of crp protein levels (p = 0.0.001). endurance training had no significant effect on nf-κb protein levels (p = 0.172), however, the purslane seed consumption had a significant effect on the reduction of nf-κb (p = 0.0.001), and endurance training with purslane seed consumption had interactive effects on reduction of nf-κb (p = 0.0.001). conclusions: it appears that endurance training with concurrent consumption of purslane seed has interactive effects on the reduction of nf-κb and crp in the heart tissue of rats poisoned by h2 o2 .