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   alteration of lipid peroxidation and total antioxidant capacity in patients with head and neck cancers following radiotherapy  
   
نویسنده manifar soheila ,abbassi farid ,mirzaii dizgah iraj ,khatami roya ,esmseil mostafa ,almasi afshin
منبع journal of archives in military medicine - 2015 - دوره : 3 - شماره : 4 - صفحه:1 -0
چکیده    background]head and neck cancers are one of the main causes of cancer related death in the world. the common approach in the treatment of head and neck cancers is radiotherapy either alone or in combination with other therapeutic strategies.[objectives]the aim of this study was to evaluate the effects of radiotherapy on lipid peroxidation and total antioxidant levels as biomarkers of oxidative stress in patients with head and neck cancers.[patients and methods]head and neck cancers were documented by two blinded expert pathologists. whole saliva samples were collected from 30 patients with head and neck cancers before and after radiotherapy and 30 healthy individuals. the unstimulated whole saliva malondialdehyde (mda), as an indicator of lipid peroxidation, and total antioxidant capacity (tac) were assayed by thiobarbituric acid and decolorization of abts radical cation method, respectively. data was analyzed by anova followed by tukey’s post hoc test.[results]the levels of antioxidants capacity were significantly increased before radiotherapy in patients in comparison to healthy control (p lt; 0.05). moreover, antioxidants capacity levels were significantly enhanced after radiotherapy in patients. furthermore, lipid oxidation levels slightly decreased after radiotherapy in nonsignificant manner.[conclusions]lipid peroxidation slightly reduced in patients with head and neck cancers after radiotherapy. however, antioxidant status improved in these patients after radiotherapy.
کلیدواژه antioxidant ,head and neck neoplasms ,malondialdehyde ,oxidative stress ,radiotherapy
آدرس tehran university of medical sciences, school of dentistry, department of oral and dental disease, iran, shahed university, school of dentistry, department of oral and dental disease, iran, aja university of medical sciences, school of medicine, department of physiology, iran, shahed university, school of dentistry, department of oral and dental disease, iran, shahed university, school of dentistry, department of oral and dental disease, iran, kermanshah university of medical sciences, clinical research development center, school of public health, department of biostatistics and epidemiology, iran
 
 

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