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   effect of high intensity interval training with flaxseed on interleukin-1 beta and lipocalin-2 gene expressions in the heart tissue of rats  
   
نویسنده khademi younes ,hosseini ali ,dana fatemeh ,hamidi azar ,azadmanesh majid ,pirouz mehdi
منبع journal of archives in military medicine - 2018 - دوره : 6 - شماره : 4 - صفحه:1 -7
چکیده    background: inflammation plays an important role in the development of atherosclerosis. interleukin-1 beta (il-1β) and lipocalin-2 (lcn-2) are important inflammatory markers in the pathogenesis of atherosclerosis. objectives: this study aimed to investigate the interactive effects of high intensity interval exercises (hiit) with flaxseed oil consumption on il-1β and lcn-2 gene expressions in the heart tissue of rats. methods: in this experimental study, 20 adult male wistar rats were randomly selected and divided into four groups of five rats: (1) control, (2) hiit, (3) 20 mg/kg of flaxseed oil, and (4) hiit with mg/kg 20 flaxseed oil. groups 2 and 4 ran on a treadmill for 10 weeks and five weeks each, with 90% to 95% intensity of vo2max . for analysis of the research findings, kolmogorov-smirnov statistical analysis and two-way anova were used (p ≤ 0.05). results: ten weeks of hiit (p = 0.001) and flaxseed oil consumption (p = 0.03) had a significant effect on reducing the lcn-2 gene expression in the heart tissue of rats. however, 10 weeks of hiit (p = 0.19) and flaxseed oil consumption (p = 0.19) had no significant effect on il-1β gene expression in the heart tissue of rats. in addition, 10 weeks of hiit with flaxseed oil has no interactive effects on il-1β (p = 0.91) and lcn-2 (p = 0.99) in the heart tissue of rats. conclusions: although it seems that the simultaneous use of flaxseed oil with hiit does not have interactive effects on il-1β and lcn-2 gene expressions in the heart tissue of rats, the use of flaxseed oil and hiit alone results in improved lcn-2 gene expression in the heart tissue of rats.
کلیدواژه training ,flaxseed oil ,heart ,il-1β ,lcn-2
آدرس university of science and art, department of physical education, ایران, islamic azad university, marvdasht branch, department of sport physiology, ایران, islamic azad university, yazd branch, ایران, islamic azad university, bardaskan branch, department of physical education, ایران, islamic azad university, bam branch, department of physical education, ایران, islamic azad university, bam branch, department of physical education, ایران
پست الکترونیکی mehdipirooz@yahoo.com
 
 

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