Spectrophotometric determination of Chlorpromazine Hydrochloride by oxidative coupling reaction with PBromo aniline using Ammonium Ceric Sulphate Dihydrate

A new sensitive spectrophotometric method for the determination of chlorpromazine hydrochloride (cpzh) was developed. the method is based on an oxidative coupling reaction with p-bromoaniline using ammonium ceric sulphate dihydrate as oxidizing agent to produce a violet color, soluble in water, stable product and absorbs at 553 nm. beer's law was in the linear range 2.5 - 30 μg/ml of cpzh, the molar absorptivity, sandellʼs sensitivity index and detection limit were 6.5731 × 10^3 liter. mol^-1.cm^-1, 0.0541 μg.cm^-2 and 0.1361 μg/ml respectively. the rsd value was 1.20 - 1.36 % depending on the concentration. this method was applied successfully to the determination of chlorpromazine hydrochloride in two pharmaceutical formulations (tablets and injection).