Synthesis and Antibacterial Activities of Some Arabinofuranose-Schiff Bases Derivatives

As a continuous research for the discovery of new antibacterial agents due to the developing resistance toward conventional antibiotics, we reported a convenient synthetic approach for the preparation of methyl-α-d-arabinofuranoside shiff-bases. a series of arabinose-shiff bases were prepared through the trityl protection of the primary hydroxyl group of methyl-α-d-arabinofuranoside, benzoylation, the removal of the trityl protective group, tosylation, azidation, conversion to the amine in the presence of triphenylphosphine, condensing reaction with a variety of aromatic aldehydes, and subsequent debenzoylation. new compounds were characterized by ^1h nmr and ftir spectroscopy. synthesised compounds were screened for antibacterial activity against several bacterial strains namely, escherichia coli; staphylococcus aureus; bacillus subtilis; candida albicans; aspergillus niger, and they showed enhanced antibacterial activity.