Determination of Some Hematological, Biochemical Parameters and Vitamin D Receptor Gene Polymorphism in Kurdish Patients with COVID-19 in Erbil City

Coronavirus infection a new infectious illness brought on by the sars-cov-2 virus has infected people worldwide as of 2019, a covid-19 disease is associated with hematological and biochemical parameters changes. the present study aimed to evaluate the possible relationship between patient parameters and disease severity. a total of 200 nasopharyngeal swabs and whole blood specimens were collected from individuals suspected of cov-2 and healthy volunteers as control of both sexes, grouped into four groups:50 patients for each mild, moderate,and severe patients and 50 healthy volunteers. the current study demonstrated that female 82(55%) was more frequently affected than male 68(45%). hematological parameters including white blood cell count (wbc), granulocyte count, and red blood cell distribution width(rdw%) (increased significantly p value< 0.05, while lymphocyte countdecreased significantly when compared with a control group. significant differences in hemoglobin concentration, packed cell volume, red blood cell count, and indices of red blood cell count were shown when compared with a control group in both sexes. regarding biochemical parameters including serum vitamin d, ferritin, d-dimer, procalcitonin (pct), and liver function tests, serum vitamin d decreased significantly, while serum ferritin, d-dimer, procalcitonin and liver enzymes increased significantly in the covid-19 patients group compared to the control group. according to vitamin d receptor, gene polymorphism in covid-19 patients genotype bb was most likely associated and strongly related to getting infected with cov-2 virus with all the three known stages of infection. severity of cov-2 was associated with leukocytosis, lymphopenia and biomarkers are the best predictors of severe cov-2, with a strong relation of vdr gene polymorphism bsmi with the severity of cov-2 patients.