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Synthesis and Identification of Some New Thiazole Derivatives Which Derived From Pyrazoline Compounds and Evaluation the Antibacterial Activity of Some of Them
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نویسنده
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Hassan Ahmed Abdul ,Mohammed Mohsin Omar ,Qasim Ghazwan Thamir
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منبع
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Kirkuk University Journal: Scientific Studies - 2019 - دوره : 14 - شماره : 4 - صفحه:46 -62
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چکیده
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In this study some new derivatives of thiazole compounds were successfully prepared in two steps with high yields. the first step included a synthesis of a new series of pyrazoline (1a-1i) using a one-pot three components reaction. the reaction between (acetophenone4- nitroacetophenone), different substituted benzaldehyde compounds and thiosemicarbazide in absolute ethanol as a solvent with heating at reflux provided the new series of pyrazoline derivatives in a short reaction times. in the second step, the pyrazoline compounds (1a-1i) refluxed with 4-bromophenacyl bromide in absolute ethanol to produce thiazole compounds (2a-2i) in high yields. the infra-red technique (ft-ir) was used to identify the synthesised compounds and the proton nuclear magnetic resonance technique (1h-nmr) was used to identify som of them.
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کلیدواژه
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Thiazole ,Pyrazoline ,One- Pot Reaction ,Antibacterial Activity
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آدرس
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Kirkuk University, Collage Of Science, Department Of Chemistry, Iraq, Kirkuk University, Collage Of Science, Department Of Chemistry, Iraq, Kirkuk University, Collage Of Science, Department Of Chemistry, Iraq
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پست الکترونیکی
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teacherghazwan@gmai.com
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Authors
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