Synthesis, characterization and biohydrolysis drug release studies of polymer carrier with Naproxen

In the present work, the hydroxyl groups of hpmc, hpc and hec polymers bonds with bioactive material naproxen drug by esterification process. (direct esterification and indirect esterification). the modified s polymers are characterized by some spectroscopic methods such as ftir, uv, h^1. nmr and c^13. nmr. the degree of substitution (d.s) of the hydroxyl groups in suger molecule in polymer was determined in all cases. the hydrolysis of modified polymers is carried out in the heterogeneous phase in a buffer solution of ph (2.0, 7.4 and 9.0) at various temperatures (25, 37, and 45 c˚). the amounts of released naproxen drugs were quantitatively determined by using calibration curve method. biodegradation (in vitro degradation) of modification polymers is carried out by enzymatic cleavage (using lipase enzyme) at ph 7.4 (the human blood ph) and 37c˚. the amounts of released naproxen were quantitatively determined by u.v visible spectrophotometry by using the usual calibration curve method. in general, it was found that the release in presence of enzyme was faster than in hydrolysis process.