Investigating the Distribution of Ercc2 (Rs13181) Gene Polymorphism in Gastric Cancer Patients in Mazandaran: A Case-Control Study

Gastric cancer is one of the most common cancers of the gastrointestinal tract in the world, which also has a high prevalence in iran. ercc2 gene is considered one of the major genes related to gastric cancer. the present study aimed to investigate the relationship between rs13181 polymorphism of ercc2 gene. the polymorphism in the promoter region of ercc2 gene can affect the activity of this gene and thus the susceptibility to gastric cancer. in this case-control study, 81 patients and 75 healthy individuals were recruited. five ml of the peripheral blood of individuals were collected in edta-containing tubes. genomic dna was extracted using the salting-out method and polymorphism was genotyped using the pcr-rflp method. the prevalence of rs13181 (g>t) genotype and polymorphism allele were significantly different between patients with gastric cancer and control group (both p <0.0001). the frequency of t allele in the gastric cancer group was 54% and in the control group was 18%, and this allele was significantly associated with the risk of gastric cancer (or= 5, ci 95%= -0.9611 to 0.5138). regarding the association of tt genotype with the studied disease, the results of this study introduce tt genotype as a protective factor in the development of disease (or= 114, 95% ci= 6.7909 to 1926.2942).our results confirmed the association between rs13181 polymorphism of ercc2 gene and the increased risk of gastric cancer in mazandaran province.