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   Study of the Expression of Mir-4270 in Plasma of Patients With Breast Invasive Ductal Carcinoma  
   
نویسنده Aminisepehr Faezeh ,Babaei Esmaeil ,Hosseinpour Feizi Mohammad Ali
منبع Journal Of Genetic Resources - 2018 - دوره : 4 - شماره : 2 - صفحه:85 -89
چکیده    Detection of tumor-specific micrornas (mirs) in the blood of cancer patients may provide a unique and valuable biomarker for diagnosis and prognosis. the aim of this study was to investigate whether plasma levels of microrna-4270 could serve as a potential marker for breast invasive ductal carcinoma. a total of 40 breast cancer patients and 28 controls were recruited in this study. total rna was extracted from plasma samples and mir-4270 expression was evaluated by real-time polymerase chain reaction (pcr). the correlation between mir-4270 expression and clinico-pathological characteristics were also studied. our data showed that plasma mir-4270 is significantly upregulated in patients compared to control group (p-value=0.00). in addition, data analysis illustrated a correlation between low plasma levels of mir-4270 and larger tumor size, lymph node metastasis and higher stages of malignancy (p-value > 0.05). the area under the curve of the roc revealed that mir-4270 expression was not able to distinguish between tumor plasmas and nontumoral specimens. current work shows preliminary data on the expression profile of mir-4270 in plasma of breast cancer patients. however, further studies are required to fully elucidate the role of circulating mir-4270 in breast ductal carcinoma.
کلیدواژه Circulating Microrna; Mir-4270; Breast Cancer; Real-Time Pcr
آدرس University Of Tabriz, School Of Natural Sciences, Department Of Biological Sciences, ایران, University Of Tabriz, School Of Natural Sciences, Department Of Biological Sciences, ایران, University Of Tabriz, School Of Natural Sciences, Department Of Biological Sciences, ایران
پست الکترونیکی pourfeizi@eastp.ac.ir
 
 

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