Study of the Expression of Mir-4270 in Plasma of Patients With Breast Invasive Ductal Carcinoma

Detection of tumor-specific micrornas (mirs) in the blood of cancer patients may provide a unique and valuable biomarker for diagnosis and prognosis. the aim of this study was to investigate whether plasma levels of microrna-4270 could serve as a potential marker for breast invasive ductal carcinoma. a total of 40 breast cancer patients and 28 controls were recruited in this study. total rna was extracted from plasma samples and mir-4270 expression was evaluated by real-time polymerase chain reaction (pcr). the correlation between mir-4270 expression and clinico-pathological characteristics were also studied. our data showed that plasma mir-4270 is significantly upregulated in patients compared to control group (p-value=0.00). in addition, data analysis illustrated a correlation between low plasma levels of mir-4270 and larger tumor size, lymph node metastasis and higher stages of malignancy (p-value > 0.05). the area under the curve of the roc revealed that mir-4270 expression was not able to distinguish between tumor plasmas and nontumoral specimens. current work shows preliminary data on the expression profile of mir-4270 in plasma of breast cancer patients. however, further studies are required to fully elucidate the role of circulating mir-4270 in breast ductal carcinoma.