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   the association of neuromyelitis optica without myelitis and systemic lupus erythematosus: a case report  
   
نویسنده jokar mohammad hassan ,azami asal
منبع case reports in clinical practice - 2017 - دوره : 2 - شماره : 3 - صفحه:71 -74
چکیده    systemic lupus erythematosus is an autoimmune disease. neuromyelitis optica (devic’s disease) is an inflammatory disorder belonging to the central nervous system. the typical characterizations include severe, immune-mediated demyelination, and axonal damage which mostly involve optic nerves and spinal cord, also the brain and brainstem. anti-aquaporin- 4 antibody has been recently described as a highly specific marker for neuromyelitis optica. neuromyelitis optica occasionally is linked with systemic autoimmune disorders, including systemic lupus erythematosus. here, we describe a 26-year-old young woman with systemic lupus erythematosus who had bilateral optic neuritis with no evidence of myelitis or other core clinical criteria. however, aquaporin 4 antibody with high titer was detected. the patient received high-dose prednisolone, cyclophsphamid, and rituximab; but this treatment caused no change in her visual acuity. in patients with systemic lupus erythematosus who complicated by optic neuritis (with or without myelitis), the association of neuromyelitis optica should be considered.
کلیدواژه systemic lupus erythematosus ,neuromyelitis optica ,aquaporin 4
آدرس mashhad university of medical sciences, imam reza hospital, department of internal medicine, ایران, mashhad university of medical sciences, school of medicine, department of rheumatology, ایران
 
 

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