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   fatal pancytopenia associated with radium-223 dichloride in a patient with castration-resistant prostate cancer and multiple bone metastases  
   
نویسنده hama yukihiro ,koga shoji
منبع case reports in clinical practice - 2017 - دوره : 2 - شماره : 3 - صفحه:63 -66
چکیده    radium-223 dichloride (ra-223) is an alpha-emitting radioisotope that targets osteoblastic metastasis of prostate cancer. for ra-223, a favorable safety profile has been described. however, here we report a case of a fatal hematologic toxicity following the administration of ra-223 observed at our hospital. an 80-year-old man with castration-resistant prostate cancer (crpc) and multiple metastatic bone lesions was treated with ra-223. he was complicated with systemic edema, constipation, and decline of renal function. one week later, he developed pancytopenia which deteriorated gradually, and died with severe prolonged pancytopenia and pneumonia 4 weeks after administration of ra-223. our report demonstrates the risk of fatal hematologic toxicity of ra-223 even though pretreatment clinical and laboratory findings fulfill the selection criteria. caution should be paid when prescribing ra-223 to a patient with systemic edema, constipation, and decline of renal function.
کلیدواژه radionuclide ,hematology ,radiation effects
آدرس edogawa hospital, department of radiology, japan, edogawa hospital, department of urology, japan
 
 

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