multiple primary metachronous malignancies, namely kidney, colon, uterus, and breast cancer: a case report

The incidence of multiple primary malignancies (mpms) has risen in clinical practice; however, cases involving three or more primary cancers remain rare. a 56-year-old postmenopausal female with a significant familial cancer history developed four primary malignancies: papillary renal cell carcinoma, endometrial stromal sarcoma, colon adenocarcinoma, and invasive ductal carcinoma of the breast. the patient passed away after one year of receiving palliative treatment for her metastatic breast cancer. this study reviews 33 cases of mpms, primarily involving breast, colon, and uterine cancers, mostly in women over 60. genetic predisposition plays a significant role, with 35.5% having hereditary cancer syndromes. this report emphasizes the importance of considering new masses in cancer patients as potential new malignancies. early detection usingfluorodeoxyglucose positron emission tomography (fdg-pet), implementing genetic testing, and timely cancer screenings in high-risk families significantly improve patient outcomes and management.