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Azathioprine-Induced Severe Bone Marrow Suppression
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نویسنده
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Ghalamkari Marzieh ,Karimpour Reyhan Sahar ,Khajavi Rad Nasim ,Abbaszadeh Mahsa
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منبع
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Case Reports In Clinical Practice - 2019 - دوره : 4 - شماره : 1 - صفحه:9 -13
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چکیده
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Aplastic anemia is characterized by bone marrow failure and pancytopenia. it could be due to autoimmune disorders, radiation, drugs, or chemicals. drugs that mostly cause aplastic anemia include chloramphenicol, nonsteroidal antiinflammatory drugs, antiepileptic drugs, gold salts, and antithyroid drugs. clinical sign and symptoms often result from pancytopenia that includes signs of anemia and bleeding. in some patients, fever and sepsis are seen that are due to neutropenia. azathioprine is a purine antimetabolite, an immunosuppressive drug that causes myelosuppression and pancytopenia, especially in patients who have some degrees of tpmt (thiopurine methyltransferase) activity. we present a patient who admitted to our hospital with fever and pancytopenia and a history of recent azathioprine treatment. because of delay in the recovery of pancytopenia, she was suspected of aplastic anemia, and bone marrow aspiration and biopsy were done for her.
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کلیدواژه
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Aplastic Anemia ,Azathioprine ,Pancytopenia
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آدرس
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Tehran University Of Medical Sciences, Cancer Institute, Imam Khomeini Hospital Complex, Department Of Internal Medicine, Iran, Tehran University Of Medical Sciences, Imam Khomeini Hospital Complex, Department Of Internal Medicine, Iran, Tehran University Of Medical Sciences, Imam Khomeini Hospital Complex, Department Of Internal Medicine, Iran, Tehran University Of Medical Sciences, Imam Khomeini Hospital Complex, Department Of Internal Medicine, Iran
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پست الکترونیکی
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mahsa.abbaszadeh@yahoo.com
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Authors
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